Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder.

Autor: Mazumder AH; Department of Psychiatry, Research Unit of Clinical Neuroscience, University of Oulu, 90014 Oulu, Finland., Barnett J; Cambridge Cognition, University of Cambridge, Cambridge CB25 9TU, UK., Isometsä ET; Department of Psychiatry, University Hospital and University of Helsinki, 00029 Helsinki, Finland., Lindberg N; Department of Psychiatry, University Hospital and University of Helsinki, 00029 Helsinki, Finland., Torniainen-Holm M; Mental Health Unit, Finnish Institute for Health and Welfare (THL), 00271 Helsinki, Finland., Lähteenvuo M; Department of Forensic Psychiatry, Niuvanniemi Hospital, University of Eastern Finland, 70240 Kuopio, Finland.; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland., Lahdensuo K; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland.; Mehiläinen, Pohjoinen Hesperiankatu 17 C, 00260 Helsinki, Finland., Kerkelä M; Department of Psychiatry, Research Unit of Clinical Neuroscience, University of Oulu, 90014 Oulu, Finland., Ahola-Olli A; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland., Hietala J; Department of Psychiatry, University of Turku, 20014 Turku, Finland.; Department of Psychiatry, Turku University Hospital, 20521 Turku, Finland., Kampman O; Faculty of Medicine and Health Technology, Tampere University, 33014 Tampere, Finland.; Department of Psychiatry, Pirkanmaa Hospital District, 33521 Tampere, Finland., Kieseppä T; Department of Psychiatry, University Hospital and University of Helsinki, 00029 Helsinki, Finland.; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland.; Mehiläinen, Pohjoinen Hesperiankatu 17 C, 00260 Helsinki, Finland., Jukuri T; Department of Psychiatry, Research Unit of Clinical Neuroscience, University of Oulu, 90014 Oulu, Finland.; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland., Häkkinen K; Department of Forensic Psychiatry, Niuvanniemi Hospital, University of Eastern Finland, 70240 Kuopio, Finland.; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland., Cederlöf E; Mental Health Unit, Finnish Institute for Health and Welfare (THL), 00271 Helsinki, Finland., Haaki W; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland.; Department of Psychiatry, University of Turku, 20014 Turku, Finland., Kajanne R; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland., Wegelius A; Department of Psychiatry, University Hospital and University of Helsinki, 00029 Helsinki, Finland.; Mental Health Unit, Finnish Institute for Health and Welfare (THL), 00271 Helsinki, Finland.; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland., Männynsalo T; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland.; Social Services and Health Care Sector, City of Helsinki, 00099 Helsinki, Finland., Niemi-Pynttäri J; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland.; Social Services and Health Care Sector, City of Helsinki, 00099 Helsinki, Finland., Suokas K; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland.; Faculty of Medicine and Health Technology, Tampere University, 33014 Tampere, Finland., Lönnqvist J; Mental Health Unit, Finnish Institute for Health and Welfare (THL), 00271 Helsinki, Finland.; Department of Psychiatry, University of Helsinki, 00014 Helsinki, Finland., Tiihonen J; Department of Forensic Psychiatry, Niuvanniemi Hospital, University of Eastern Finland, 70240 Kuopio, Finland.; Department of Clinical Neuroscience, Karolinska Institute, 17177 Stockholm, Sweden.; Center for Psychiatry Research, Stockholm City Council, 11364 Stockholm, Sweden., Paunio T; Department of Psychiatry, University Hospital and University of Helsinki, 00029 Helsinki, Finland.; Mental Health Unit, Finnish Institute for Health and Welfare (THL), 00271 Helsinki, Finland.; Department of Psychiatry, University of Helsinki, 00014 Helsinki, Finland., Vainio SJ; Infotech Oulu, University of Oulu, 90014 Oulu, Finland.; Northern Finland Biobank Borealis, Oulu University Hospital, 90220 Oulu, Finland.; Faculty of Biochemistry and Molecular Medicine, University of Oulu, 90014 Oulu, Finland.; Kvantum Institute, University of Oulu, 90014 Oulu, Finland., Palotie A; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland.; Mehiläinen, Pohjoinen Hesperiankatu 17 C, 00260 Helsinki, Finland.; Stanley Center for Psychiatric Research, The Broad Institute of MIT (Massachusetts Institute of Technology) and Harvard, Cambridge, MA 02142, USA.; Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA., Niemelä S; Department of Psychiatry, University of Turku, 20014 Turku, Finland.; Department of Psychiatry, Turku University Hospital, 20521 Turku, Finland., Suvisaari J; Mental Health Unit, Finnish Institute for Health and Welfare (THL), 00271 Helsinki, Finland., Veijola J; Department of Psychiatry, Research Unit of Clinical Neuroscience, University of Oulu, 90014 Oulu, Finland.; Department of Psychiatry, Oulu University Hospital, 90220 Oulu, Finland.
Jazyk: angličtina
Zdroj: Brain sciences [Brain Sci] 2021 Oct 27; Vol. 11 (11). Date of Electronic Publication: 2021 Oct 27.
DOI: 10.3390/brainsci11111422
Abstrakt: The purpose of this study was to explore the association of cognition with hazardous drinking Polygenic Scores (PGS) in 2649 schizophrenia, 558 schizoaffective disorder, and 1125 bipolar disorder patients in Finland. Hazardous drinking PGS was computed using the LDPred program. Participants performed two computerized tasks from the Cambridge Automated Neuropsychological Test Battery (CANTAB) on a tablet computer: the 5-choice serial reaction time task, or Reaction Time (RT) test, and the Paired Associative Learning (PAL) test. The association between hazardous drinking PGS and cognition was measured using four cognition variables. Log-linear regression was used in Reaction Time (RT) assessment, and logistic regression was used in PAL assessment. All analyses were conducted separately for males and females. After adjustment of age, age of onset, education, household pattern, and depressive symptoms, hazardous drinking PGS was not associated with reaction time or visual memory in male or female patients with schizophrenia, schizoaffective, and bipolar disorder.
Databáze: MEDLINE
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