High levels of donor-derived cell-free DNA in a case of graft-versus-host-disease following liver transplantation.

Autor: Lewis D; Department of Surgery, College of Medicine, University of Florida, Gainesville, Florida., Glehn-Ponsirenas R; Medical Affairs Department, CareDx, Inc., Brisbane, California., Gulbahce N; Research & Development Department, CareDx, Inc., Brisbane, California., Hooey LJ; Department of Dermatology, College of Medicine, University of Florida, Gainesville, Florida., Chaffin JM; Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, Florida., Miles J; Medical Affairs Department, CareDx, Inc., Brisbane, California., Woodward R; Research & Development Department, CareDx, Inc., Brisbane, California., Duarte S; Department of Surgery, College of Medicine, University of Florida, Gainesville, Florida., Beduschi T; Department of Surgery, College of Medicine, University of Florida, Gainesville, Florida., Zarrinpar A; Department of Surgery, College of Medicine, University of Florida, Gainesville, Florida.
Jazyk: angličtina
Zdroj: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [Am J Transplant] 2022 Mar; Vol. 22 (3), pp. 973-976. Date of Electronic Publication: 2021 Dec 06.
DOI: 10.1111/ajt.16894
Abstrakt: The diagnosis of graft-versus-host-disease (GVHD) after solid organ transplantation is made difficult by its variable clinical presentation and lack of sensitive and specific biomarkers to evaluate the immune state of transplant recipients. Emerging noninvasive diagnostic techniques like the quantification of donor-derived cell-free DNA (dd-cfDNA) for surveillance may improve the current standard-of-care. Herein, we report the use of this methodology in a patient with GVHD and corresponding levels of dd-cfDNA without any evidence of graft injury. Correlation of dd-cfDNA levels with the clinical course and its novel application here could lead to improvements in the rapid diagnosis of GVHD and in monitoring of response to treatment.
(© 2021 The American Society of Transplantation and the American Society of Transplant Surgeons.)
Databáze: MEDLINE
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