Correction of depression-associated circadian rhythm abnormalities is associated with lithium response in bipolar disorder.

Autor: Federoff M; Department of Psychiatry, University of California San Diego, La Jolla, California, USA., McCarthy MJ; Department of Psychiatry, University of California San Diego, La Jolla, California, USA.; Department of Psychiatry, VA San Diego Healthcare System, La Jolla, California, USA., Anand A; Department of Psychiatry, Case Western Reserve University, Cleveland, Ohio, USA., Berrettini WH; University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Bertram H; University of Michigan, Ann Arbor, Michigan, USA., Bhattacharjee A; Department of Psychiatry, University of California San Diego, La Jolla, California, USA.; Department of Psychiatry, VA San Diego Healthcare System, La Jolla, California, USA., Calkin CV; Dalhousie University, Halifax, Canada., Conroy C; Department of Psychiatry, Case Western Reserve University, Cleveland, Ohio, USA., Coryell WH; University of Iowa, Iowa City, Iowa, USA., D'Arcangelo N; Department of Psychiatry, Case Western Reserve University, Cleveland, Ohio, USA., DeModena A; Department of Psychiatry, VA San Diego Healthcare System, La Jolla, California, USA., Fisher C; Departments of Psychiatry and Medical and Molecular Genetics, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, USA., Feeder S; Mayo Clinic, Rochester, Minnesota, USA., Frazier N; University of Michigan, Ann Arbor, Michigan, USA., Frye MA; Mayo Clinic, Rochester, Minnesota, USA., Gao K; Department of Psychiatry, Case Western Reserve University, Cleveland, Ohio, USA., Garnham J; Dalhousie University, Halifax, Canada., Gershon ES; University of Chicago, Chicago, Illinois, USA., Alliey-Rodriguez N; University of Chicago, Chicago, Illinois, USA., Glazer K; Department of Psychiatry and Behavioral Sciences, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA., Goes F; Department of Psychiatry and Behavioral Sciences, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA., Karberg T; Department of Psychiatry, Case Western Reserve University, Cleveland, Ohio, USA., Harrington G; University of Michigan, Ann Arbor, Michigan, USA., Jakobsen P; NORMENT, Division of Psychiatry, Haukeland University Hospital, Bergen, Norway.; Department of Clinical Medicine, University of Bergen, Norway., Kamali M; University of Michigan, Ann Arbor, Michigan, USA., Kelly M; University of Michigan, Ann Arbor, Michigan, USA., Leckband SG; Department of Psychiatry, VA San Diego Healthcare System, La Jolla, California, USA., Lohoff F; University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Maihofer AX; Department of Psychiatry, University of California San Diego, La Jolla, California, USA., McInnis MG; University of Michigan, Ann Arbor, Michigan, USA., Mondimore F; Department of Psychiatry and Behavioral Sciences, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA., Morken G; Division of Psychiatry, St. Olav University Hospital of Trondheim and Department of Neuroscience, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway., Nurnberger JI; Departments of Psychiatry and Medical and Molecular Genetics, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, USA., Oedegaard KJ; NORMENT, Division of Psychiatry, Haukeland University Hospital, Bergen, Norway.; Department of Clinical Medicine, University of Bergen, Norway., Ritchey M; Department of Psychiatry and Behavioral Sciences, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA., Ryan K; University of Michigan, Ann Arbor, Michigan, USA., Schinagle M; Department of Psychiatry, Case Western Reserve University, Cleveland, Ohio, USA., Schoeyen H; Department of Clinical Medicine, University of Bergen, Norway.; Clinic of Adult Psychiatry, Stavanger University Hospital, Stavanger, Norway., Schwebel C; University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Shaw M; University of Chicago, Chicago, Illinois, USA., Shilling PD; Department of Psychiatry, University of California San Diego, La Jolla, California, USA., Slaney C; Dalhousie University, Halifax, Canada., Stautland A; Department of Clinical Medicine, University of Bergen, Norway., Tarwater B; University of Iowa, Iowa City, Iowa, USA., Calabrese JR; Department of Psychiatry, Case Western Reserve University, Cleveland, Ohio, USA., Alda M; Dalhousie University, Halifax, Canada., Nievergelt CM; Department of Psychiatry, University of California San Diego, La Jolla, California, USA., Zandi PP; Department of Psychiatry and Behavioral Sciences, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA., Kelsoe JR; Department of Psychiatry, University of California San Diego, La Jolla, California, USA.
Jazyk: angličtina
Zdroj: Bipolar disorders [Bipolar Disord] 2022 Aug; Vol. 24 (5), pp. 521-529. Date of Electronic Publication: 2021 Dec 06.
DOI: 10.1111/bdi.13162
Abstrakt: Background: Bipolar disorder (BD) is characterized by episodes of depression and mania and disrupted circadian rhythms. Lithium is an effective therapy for BD, but only 30%-40% of patients are fully responsive. Preclinical models show that lithium alters circadian rhythms. However, it is unknown if the circadian rhythm effects of lithium are essential to its therapeutic properties.
Methods: In secondary analyses of a multi-center, prospective, trial of lithium for BD, we examined the relationship between circadian rhythms and therapeutic response to lithium. Using standardized instruments, we measured morningness, diurnal changes in mood, sleep, and energy (circadian rhythm disturbances) in a cross-sectional study of 386 BD subjects with varying lithium exposure histories. Next, we tracked symptoms of depression and mania prospectively over 12 weeks in a subset of 88 BD patients initiating treatment with lithium. Total, circadian, and affective mood symptoms were scored separately and analyzed.
Results: Subjects with no prior lithium exposure had the most circadian disruption, while patients stable on lithium monotherapy had the least. Patients who were stable on lithium with another drug or unstable on lithium showed intermediate levels of disruption. Treatment with lithium for 12 weeks yielded significant reductions in total and affective depression symptoms. Lithium responders (Li-Rs) showed improvement in circadian symptoms of depression, but non-responders did not. There was no difference between Li-Rs and nonresponders in affective, circadian, or total symptoms of mania.
Conclusions: Exposure to lithium is associated with reduced circadian disruption. Lithium response at 12 weeks was selectively associated with the reduction of circadian depressive symptoms. We conclude that stabilization of circadian rhythms may be an important feature of lithium's therapeutic effects.
Clinical Trials Registry: NCT0127253.
(© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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