Myeloperoxidase as an important predictor of cardiovascular risk in individuals with rheumatoid arthritis.

Autor: Montes EG; Department of Clinical and Toxicological Analysis, State University of Ponta Grossa-UEPG, Avenue General Carlos Cavalcanti, 4748, Ponta Grossa-PR, Uvaranas, CEP: 84030-900, Brazil., Mansani FP; Department of Medicine, State University of Ponta Grossa-UEPG, Ponta Grossa-PR, Brazil., de Oliveira Toledo Júnior A; Department of Clinical and Toxicological Analysis, State University of Ponta Grossa-UEPG, Avenue General Carlos Cavalcanti, 4748, Ponta Grossa-PR, Uvaranas, CEP: 84030-900, Brazil., Schafranski MD; Department of Medicine, State University of Ponta Grossa-UEPG, Ponta Grossa-PR, Brazil., Zardo BQ; Department of Clinical and Toxicological Analysis, State University of Ponta Grossa-UEPG, Avenue General Carlos Cavalcanti, 4748, Ponta Grossa-PR, Uvaranas, CEP: 84030-900, Brazil., Dos Santos FA; Department of Odontology, State University of Ponta Grossa-UEPG, Ponta Grossa-PR, Brazil., Grassiolli S; Department of Biology, State University of West-UNIOESTE, Cascavel-PR, Brazil., de Freitas Calixto L; Department of Medicine, State University of Ponta Grossa-UEPG, Ponta Grossa-PR, Brazil., da Costa RL; Department of Medicine, State University of Ponta Grossa-UEPG, Ponta Grossa-PR, Brazil., de Freitas Netto F; Department of Medicine, State University of Ponta Grossa-UEPG, Ponta Grossa-PR, Brazil., Vellosa JCR; Department of Clinical and Toxicological Analysis, State University of Ponta Grossa-UEPG, Avenue General Carlos Cavalcanti, 4748, Ponta Grossa-PR, Uvaranas, CEP: 84030-900, Brazil. vellosajcr@hotmail.com.
Jazyk: angličtina
Zdroj: Inflammopharmacology [Inflammopharmacology] 2021 Dec; Vol. 29 (6), pp. 1819-1827. Date of Electronic Publication: 2021 Nov 26.
DOI: 10.1007/s10787-021-00892-x
Abstrakt: Background: Rheumatoid arthritis is an inflammatory disease with joint manifestations. In the presence of extra-articular manifestations, the morbidity and severity of the disease increase. Glucocorticoid is used as a treatment and may result in side effects related to cardiovascular risk.
Methods: This was a cross-sectional study including 59 volunteers with rheumatoid arthritis receiving treatment at a hospital of Campos Gerais that aimed to establish the relation between cardiovascular risk, glucocorticoid treatment and myeloperoxidase in these patients. Subjects were divided into two groups: using (n = 39) and without glucocorticoids (n = 20). They underwent clinical evaluation, physical examination and blood samples were taken. Statistical analysis was performed using Student's t test and Mann-Whitney test. Logistic regression was performed to assess the cardiovascular risk. The significance level was 5% (α = 0.05). Calculations were performed using the Statistical Package for the Social Science version 21.0.
Results: There has been a significant difference between groups in blood glucose values (p = 0.012), which can be explained by the different percentage of diabetic patients in the groups. When assessing cardiovascular risk using the predictors of glucocorticoid dose, time of glucocorticoid use, myeloperoxidase, and C-reactive protein together, these were responsible for significantly predicting this risk (p = 0.015).
Conclusion: A significant relation between the predictor myeloperoxidase alone was also demonstrated (p = 0.037), it may be an important predictor of cardiovascular risk among individuals with rheumatoid arthritis.
(© 2021. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)
Databáze: MEDLINE
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