Interrater agreement of contouring of the neurovascular bundles and internal pudendal arteries in neurovascular-sparing magnetic resonance-guided radiotherapy for localized prostate cancer.

Autor:	Teunissen FR; Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, the Netherlands., Wortel RC; Department of Oncological Urology, University Medical Center Utrecht, Utrecht, the Netherlands., Wessels FJ; Department of Radiology, University Medical Center Utrecht, Utrecht, the Netherlands., Claes A; Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, the Netherlands., van de Pol SMG; Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, the Netherlands., Rasing MJA; Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, the Netherlands., Meijer RP; Department of Oncological Urology, University Medical Center Utrecht, Utrecht, the Netherlands., van Melick HHE; Department of Urology, St. Antonius Hospital, Nieuwegein, Utrecht, the Netherlands., de Boer JCJ; Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, the Netherlands., Verkooijen HM; Imaging and Oncology Division, University Medical Center Utrecht, Utrecht, the Netherlands.; Utrecht University, Utrecht, the Netherlands., van der Voort van Zyp JRN; Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, the Netherlands.
Jazyk:	angličtina
Zdroj:	Clinical and translational radiation oncology [Clin Transl Radiat Oncol] 2021 Nov 14; Vol. 32, pp. 29-34. Date of Electronic Publication: 2021 Nov 14 (Print Publication: 2022).
DOI:	10.1016/j.ctro.2021.11.005
Abstrakt:	Background and Purpose: Radiation damage to neural and vascular tissue, such as the neurovascular bundles (NVBs) and internal pudendal arteries (IPAs), during radiotherapy for prostate cancer (PCa) may cause erectile dysfunction. Neurovascular-sparing magnetic resonance-guided adaptive radiotherapy (MRgRT) aims to preserve erectile function after treatment. However, the NVBs and IPAs are not routinely contoured in current radiotherapy practice. Before neurovascular-sparing MRgRT for PCa can be implemented, the interrater agreement of the contouring of the NVBs and IPAs on pre-treatment MRI needs to be assessed. Materials and Methods: Four radiation oncologists independently contoured the prostate, NVB, and IPA in an unselected consecutive series of 15 PCa patients, on pre-treatment MRI. Dice similarity coefficients (DSCs) for pairwise interrater agreement of contours were calculated. Additionally, the DCS of a subset of the inferior half of the NVB contours (i.e. approximately prostate midgland to apex level) was calculated. Results: Median overall interrater DSC for the left and right NVB was 0.60 (IQR: 0.54 - 0.68) and 0.61 (IQR: 0.53 - 0.69) respectively and for the left and right IPA 0.59 (IQR: 0.53 - 0.64) and 0.59 (IQR: 0.52 - 0.64) respectively. Median overall interrater DSC for the inferior half of the left NVB was 0.67 (IQR: 0.58 - 0.74) and 0.67 (IQR: 0.61 - 0.71) for the right NVB. Conclusion: We found that the interrater agreement for the contouring of the NVB and IPA improved with enhancement of the MRI sequence as well as further training of the raters. The agreement was best in the subset of the inferior half of the NVB, where a good agreement is clinically most relevant for neurovascular-sparing MRgRT for PCa. Competing Interests: The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: HV receives research funding from Elekta. The remaining authors declare no potential competing interests. (© 2021 The Author(s).)
Databáze:	MEDLINE
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