Plasma virome and the risk of blood-borne infection in persons with substance use disorder.

Autor: Kandathil AJ; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Cox AL; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Page K; Department of Internal Medicine, University of New Mexico, Albuquerque, NM, USA., Mohr D; Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Razaghi R; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Ghanem KG; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Tuddenham SA; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Hsieh YH; Department of Emergency Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Evans JL; Department of Medicine, University of California San Francisco, San Francisco, CA, USA., Coller KE; Core Diagnostics, Abbott Laboratories, Abbott Park, IL, USA., Timp W; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Celentano DD; Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA., Ray SC; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Thomas DL; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. dthomas@jhmi.edu.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2021 Nov 25; Vol. 12 (1), pp. 6909. Date of Electronic Publication: 2021 Nov 25.
DOI: 10.1038/s41467-021-26980-8
Abstrakt: There is an urgent need for innovative methods to reduce transmission of bloodborne pathogens like HIV and HCV among people who inject drugs (PWID). We investigate if PWID who acquire non-pathogenic bloodborne viruses like anelloviruses and pegiviruses might be at greater risk of acquiring a bloodborne pathogen. PWID who later acquire HCV accumulate more non-pathogenic viruses in plasma than matched controls who do not acquire HCV infection. Additionally, phylogenetic analysis of those non-pathogenic virus sequences reveals drug use networks. Here we find first in Baltimore and confirm in San Francisco that the accumulation of non-pathogenic viruses in PWID is a harbinger for subsequent acquisition of pathogenic viruses, knowledge that may guide the prioritization of the public health resources to combat HIV and HCV.
(© 2021. The Author(s).)
Databáze: MEDLINE
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