Neuropsychological and clinical findings of Cognitive Remediation Therapy feasibility randomised controlled trial in young people with anorexia nervosa.

Autor: Giombini L; Rhodes Wood Hospital, Elysium Healthcare, London, UK.; Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, PO59 King's College London, London, UK., Nesbitt S; Rhodes Wood Hospital, Elysium Healthcare, London, UK., Kusosa R; Rhodes Wood Hospital, Elysium Healthcare, London, UK., Fabian C; Rhodes Wood Hospital, Elysium Healthcare, London, UK., Sharia T; Department of Mathematics, Royal Holloway University of London, Egham, Surrey, UK., Easter A; Department of Women and Children's Health, Faculty of Life Sciences & Medicine, School of Life Course Science, King's College London, London, UK., Tchanturia K; Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, PO59 King's College London, London, UK.; Department of Psychology, Illia University Tbilisi, Tbilisi, Georgia.; South London and Maudsley NHS Foundation Trust, Eating Disorders National Service, London, UK.
Jazyk: angličtina
Zdroj: European eating disorders review : the journal of the Eating Disorders Association [Eur Eat Disord Rev] 2022 Jan; Vol. 30 (1), pp. 50-60. Date of Electronic Publication: 2021 Nov 24.
DOI: 10.1002/erv.2874
Abstrakt: Objective: Randomised controlled trial (RCT) in adults with anorexia nervosa (AN) showed that Cognitive Remediation Therapy (CRT) enhances cognitive flexibility, abstract thinking and quality-of-life. Despite inconsistent findings, CRT has the potential as an adjunct treatment for young people (YP) with AN. A feasibility RCT was conducted in an inpatient setting. The study will also consider the effect of CRT in YP with AN and autistic symptoms.
Methods: Participants were randomly allocated to the Immediate or Delayed condition to receive individual CRT sessions, in addition to standard treatment. A repeated measures design was conducted.
Results: Eighty participants were recruited. The neuropsychological measures were feasible for evaluating individual CRT in YP. Significant improvements in set-shifting and central coherence were found, with no main effect between immediate and delayed condition. Significant interactions were found between the condition, and autism spectrum condition (ASC) and No-ASC subgroup, with significant positive impact of CRT on set-shifting in the No-ASC subgroup. There was some evidence that for the No-ASC subgroup, CRT was more effective if delivered at the start of the treatment; and for the ASC subgroup, that CRT was more effective if delivered at the later stage of treatment.
Conclusions: These findings suggest that the overall positive effect of CRT in set-shifting and central coherence alongside standard treatment. They also indicate the importance of screening for the presence of ASC which could require tailored CRT.
(© 2021 Eating Disorders Association and John Wiley & Sons Ltd.)
Databáze: MEDLINE
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