Subject-specific biomechanical analysis to estimate locations susceptible to osteoarthritis-Finite element modeling and MRI follow-up of ACL reconstructed patients.

Autor: Bolcos PO; Department of Applied Physics, University of Eastern Finland, Kuopio, Finland., Mononen ME; Department of Applied Physics, University of Eastern Finland, Kuopio, Finland., Roach KE; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA., Tanaka MS; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA., Suomalainen JS; Department of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland., Mikkonen S; Department of Applied Physics, University of Eastern Finland, Kuopio, Finland., Nissi MJ; Department of Applied Physics, University of Eastern Finland, Kuopio, Finland.; Research Unit of Medical Imaging, Physics, and Technology, University of Oulu, Oulu, Finland., Töyräs J; Department of Applied Physics, University of Eastern Finland, Kuopio, Finland.; School of Information Technology and Electrical Engineering, The University of Queensland, Brisbane, Queensland, Australia.; Science Service Center, Kuopio University Hospital, Kuopio, Finland., Link TM; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA., Souza RB; Department of Physical Therapy and Rehabilitation Science, University of California San Francisco, San Francisco, California, USA., Majumdar S; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA., Ma CB; Department of Orthopaedic Surgery, University of California San Francisco, San Francisco, California, USA., Li X; Department of Biomedical Engineering, Cleveland Clinic, Cleveland, Ohio, USA., Korhonen RK; Department of Applied Physics, University of Eastern Finland, Kuopio, Finland.
Jazyk: angličtina
Zdroj: Journal of orthopaedic research : official publication of the Orthopaedic Research Society [J Orthop Res] 2022 Aug; Vol. 40 (8), pp. 1744-1755. Date of Electronic Publication: 2021 Nov 24.
DOI: 10.1002/jor.25218
Abstrakt: The aims of this case-control study were to: (1) Identify cartilage locations and volumes at risk of osteoarthritis (OA) using subject-specific finite element (FE) models; (2) Quantify the relationships between the simulated biomechanical parameters and T 2 and T 1ρ relaxation times of magnetic resonance imaging (MRI). We created subject-specific FE models for seven patients with anterior cruciate ligament (ACL) reconstruction and six controls based on a previous proof-of-concept study. We identified locations and cartilage volumes susceptible to OA, based on maximum principal stresses and absolute maximum shear strains in cartilage exceeding thresholds of 7 MPa and 32%, respectively. The locations and volumes susceptible to OA were compared qualitatively and quantitatively against 2-year longitudinal changes in T 2 and T 1ρ relaxation times. The degeneration volumes predicted by the FE models, based on excessive maximum principal stresses, were significantly correlated (r = 0.711, p < 0.001) with the degeneration volumes determined from T 2 relaxation times. There was also a significant correlation between the predicted stress values and changes in T 2 relaxation time (r = 0.649, p < 0.001). Absolute maximum shear strains and changes in T 1ρ relaxation time were not significantly correlated. Five out of seven patients with ACL reconstruction showed excessive maximum principal stresses in either one or both tibial cartilage compartments, in agreement with follow-up information from MRI. Expectedly, for controls, the FE models and follow-up information showed no degenerative signs. Our results suggest that the presented modelling methodology could be applied to prospectively identify ACL reconstructed patients at risk of biomechanically driven OA, particularly by the analysis of maximum principal stresses of cartilage.
(© 2021 Orthopaedic Research Society. Published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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