Combined Primary Resection with Hepatic Artery Infusion Pump Implantation Is Safe for Unresectable Colorectal Liver Metastases.

Autor: Turley MC; Department of Surgery, Duke University Medical Center, 2301 Erwin Road, 7HAFS, Durham, NC, 27705, USA.; Durham, USA., Moore C; Department of Surgery, Duke University Medical Center, 2301 Erwin Road, 7HAFS, Durham, NC, 27705, USA., Creasy JM; Department of Surgery, Duke University Medical Center, 2301 Erwin Road, 7HAFS, Durham, NC, 27705, USA., Sharib J; Department of Surgery, Duke University Medical Center, 2301 Erwin Road, 7HAFS, Durham, NC, 27705, USA., Lan B; Department of Surgery, Duke University Medical Center, 2301 Erwin Road, 7HAFS, Durham, NC, 27705, USA., Thacker JKM; Department of Surgery, Duke University Medical Center, 2301 Erwin Road, 7HAFS, Durham, NC, 27705, USA., Migaly J; Department of Surgery, Duke University Medical Center, 2301 Erwin Road, 7HAFS, Durham, NC, 27705, USA., Zani S; Department of Surgery, Duke University Medical Center, 2301 Erwin Road, 7HAFS, Durham, NC, 27705, USA., Allen PJ; Department of Surgery, Duke University Medical Center, 2301 Erwin Road, 7HAFS, Durham, NC, 27705, USA., Mantyh CR; Department of Surgery, Duke University Medical Center, 2301 Erwin Road, 7HAFS, Durham, NC, 27705, USA., Lidsky ME; Department of Surgery, Duke University Medical Center, 2301 Erwin Road, 7HAFS, Durham, NC, 27705, USA.
Jazyk: angličtina
Zdroj: Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract [J Gastrointest Surg] 2022 Apr; Vol. 26 (4), pp. 764-771. Date of Electronic Publication: 2021 Nov 24.
DOI: 10.1007/s11605-021-05195-8
Abstrakt: Background: Colorectal liver metastases (CRLM) are the most common cause of disease-specific mortality in patients with colorectal cancer. Hepatic artery infusion (HAI) combined with systemic chemotherapy improves survival for these patients. The safety of colorectal resection at the time of HAI pump placement has not been well established.
Methods: Patients with CRLM who underwent combined HAI pump placement and colorectal (primary) resection or HAI pump placement alone were evaluated for perioperative outcomes, pump-specific complications, infectious complications, and time to treatment initiation. These outcomes were compared using comparative statistics.
Results: Patients who underwent combined HAI pump placement and primary resection (n = 19) vs HAI pump placement alone (n = 13) had similar demographics and rates of combined hepatectomy. Combined HAI pump placement and primary resection group had similar operative time and blood loss (both p = NS), but longer length of stay (6 vs 4 days, p = 0.02) compared to pump placement alone. Overall postoperative complications (21% vs 8%) and pump-specific complications (16% vs 31%) were similar (both p = NS). Infection rates were not different between groups, nor was time to initiation of HAI therapy (19 vs 16 days p = NS), or systemic therapy (34 vs 35 days p = NS).
Conclusion: Combining colorectal resection with HAI pump implantation is a safe surgical approach for management of unresectable CRLM. Postoperative complications, specifically infectious complications, were not increased, nor was there a delay to initiation of HAI or systemic chemotherapy. Investigation of long-term oncologic outcomes for HAI pump placement and primary tumor resection in patients with unresectable CRLM is ongoing.
(© 2021. The Society for Surgery of the Alimentary Tract.)
Databáze: MEDLINE
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