Cystatin C and Iris: Advances in the Evaluation of Kidney Function in Critically Ill Dog.

Autor:	Paes-Leme FO; Department of Clinic and Surgery, Federal University of Minas Gerais, Belo Horizonte, Brazil., Souza EM; Department of Clinic and Surgery, Federal University of Minas Gerais, Belo Horizonte, Brazil., Paes PRO; Department of Clinic and Surgery, Federal University of Minas Gerais, Belo Horizonte, Brazil., Gomes MG; Department of Clinic and Surgery, Federal University of Minas Gerais, Belo Horizonte, Brazil., Muniz FS; Department of Clinic and Surgery, Federal University of Minas Gerais, Belo Horizonte, Brazil., Campos MTG; Department of Clinic and Surgery, Federal University of Minas Gerais, Belo Horizonte, Brazil., Peixoto RB; Department of Clinic and Surgery, Federal University of Minas Gerais, Belo Horizonte, Brazil., Vaz de Melo PD; Labtest Diagnóstica S.A., Lagoa Santa, Brazil., Arndt MHL; Enzytec, Biotecnologia Ltda, Belo Horizonte, Brazil., Costa Val A; Department of Clinic and Surgery, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Jazyk:	angličtina
Zdroj:	Frontiers in veterinary science [Front Vet Sci] 2021 Nov 08; Vol. 8, pp. 721845. Date of Electronic Publication: 2021 Nov 08 (Print Publication: 2021).
DOI:	10.3389/fvets.2021.721845
Abstrakt:	Critically ill hospitalized dogs are subject to certain complications, being acute kidney injury (AKI) a common one. Early diagnosis is crucial, and Cystatin C (CysC) is a reliable and early biomarker. The International Society of Renal Interest (IRIS) states that AKI severity can be assessed by mild changes in creatinine serum levels or reduction of urine output that cannot be considered biomarkers of renal injury but failure or insufficiency. Twenty-eight dogs admitted to the Intensive Care Unit under risk factors for the development of AKI were evaluated. Blood samples were collected for determination of sCr and CysC at admission and after 24, 48, and 72 h. Urine output was measured by daily monitoring, measured by collection in a closed system. The results showed the incidence of AKI was 67.9% based on the IRIS criteria and 78.6% based on cystatin C in critically ill patients' dogs. The measurement of serum cystatin C immediately on admission to the ICU was superior in the early identification of patients with AKI when compared to the IRIS classification and serum creatinine in critically ill dogs. Competing Interests: PV was employed by company Labtest Diagnóstica S.A. MA was employed by company Enzytec, Biotecnologia Ltda. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Paes-Leme, Souza, Paes, Gomes, Muniz, Campos, Peixoto, Vaz de Melo, Arndt and Costa Val.)
Databáze:	MEDLINE
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