Thrombosis and thrombocytopenia after HPV vaccination.

Autor: Johansen S; Section of Hematology, Department of Medicine, Haukeland University Hospital, Bergen, Norway., Laegreid IJ; The Norwegian National Unit for Platelet Immunology, Division of Diagnostics, University Hospital of North Norway, Tromsø, Norway., Ernstsen SL; The Norwegian National Unit for Platelet Immunology, Division of Diagnostics, University Hospital of North Norway, Tromsø, Norway., Azrakhsh NA; Section of Hematology, Department of Medicine, Haukeland University Hospital, Bergen, Norway., Kittang AO; Section of Hematology, Department of Medicine, Haukeland University Hospital, Bergen, Norway.; Department of Clinical Science, University of Bergen, Bergen, Norway., Lindås R; Section of Hematology, Department of Medicine, Haukeland University Hospital, Bergen, Norway., Gjertsen BT; Section of Hematology, Department of Medicine, Haukeland University Hospital, Bergen, Norway.; Department of Clinical Science, University of Bergen, Bergen, Norway., Vetti N; Department of Radiology, Haukeland University Hospital, Bergen, Norway.; Department of Medical Science, University of Bergen, Bergen, Norway., Mørtberg TV; The Norwegian National Unit for Platelet Immunology, Division of Diagnostics, University Hospital of North Norway, Tromsø, Norway.; Institute of Medical Biology, University of Tromsø - The Arctic University of Norway, Tromsø, Norway., Sørvoll IH; The Norwegian National Unit for Platelet Immunology, Division of Diagnostics, University Hospital of North Norway, Tromsø, Norway., Holme PA; Department of Hematology, Oslo University Hospital, Norway.; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Norway., Ahlen MT; The Norwegian National Unit for Platelet Immunology, Division of Diagnostics, University Hospital of North Norway, Tromsø, Norway., Reikvam H; Section of Hematology, Department of Medicine, Haukeland University Hospital, Bergen, Norway.; Department of Clinical Science, University of Bergen, Bergen, Norway.
Jazyk: angličtina
Zdroj: Journal of thrombosis and haemostasis : JTH [J Thromb Haemost] 2022 Mar; Vol. 20 (3), pp. 700-704. Date of Electronic Publication: 2021 Dec 07.
DOI: 10.1111/jth.15604
Abstrakt: Background: Vaccine-induced immune thrombotic thrombocytopenia (VITT) has so far only been reported after adenovirus vector severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines.
Objective: We report findings in a 25-year-old woman who presented with thrombocytopenia, venous thrombosis, elevated D-dimer levels, and high levels of platelet-activating antibodies to platelet factor 4-polyanion complexes 10 days after Gardasil 9 vaccination for human papillomavirus (HPV). The patient exhibited clinical and laboratory features in line with the recently defined VITT syndrome, described after adenoviral vector vaccination to prevent coronavirus disease 2019.
Conclusion: We report a case of VITT following HPV vaccination. This should raise awareness of the possibility of VITT also occurring after other vaccines, not exclusively adenoviral vector-based SARS-CoV-2 vaccines.
(© 2021 The Authors. Journal of Thrombosis and Haemostasis published by Wiley Periodicals LLC on behalf of International Society on Thrombosis and Haemostasis.)
Databáze: MEDLINE
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