Low levels of minimal residual disease after induction chemotherapy for BCR-ABL1-negative acute lymphoblastic leukaemia in adults are clinically relevant.

Autor: Šálek C; Institute of Haematology and Blood Transfusion, Prague, Czech Republic.; Institute of Clinical and Experimental Haematology, First Faculty of Medicine, Charles University, Prague, Czech Republic., Folber F; Department of Internal Medicine, Haematology and Oncology, University Hospital Brno, Brno, Czech Republic.; Faculty of Medicine, Masaryk University, Brno, Czech Republic., Froňková E; CLIP - Childhood Leukaemia Investigation Prague, Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic., Pecherková P; Institute of Haematology and Blood Transfusion, Prague, Czech Republic., Jelínková H; Department of Internal Medicine, Haematology and Oncology, University Hospital Brno, Brno, Czech Republic., Hrabovský Š; Department of Internal Medicine, Haematology and Oncology, University Hospital Brno, Brno, Czech Republic.; Faculty of Medicine, Masaryk University, Brno, Czech Republic., Horáček JM; Department of Internal Medicine IV - Haematology, University Hospital Hradec Králové, Hradec Králové, Czech Republic.; Department of Military Internal Medicine and Hygiene, Faculty of Military Health Sciences, University of Defence, Hradec Králové, Czech Republic., Cetkovský P; Institute of Haematology and Blood Transfusion, Prague, Czech Republic.; Institute of Clinical and Experimental Haematology, First Faculty of Medicine, Charles University, Prague, Czech Republic., Mayer J; Department of Internal Medicine, Haematology and Oncology, University Hospital Brno, Brno, Czech Republic.; Faculty of Medicine, Masaryk University, Brno, Czech Republic., Trka J; CLIP - Childhood Leukaemia Investigation Prague, Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic., Doubek M; Department of Internal Medicine, Haematology and Oncology, University Hospital Brno, Brno, Czech Republic.; Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Jazyk: angličtina
Zdroj: British journal of haematology [Br J Haematol] 2022 Feb; Vol. 196 (3), pp. 706-710. Date of Electronic Publication: 2021 Nov 23.
DOI: 10.1111/bjh.17966
Abstrakt: The aim of the present study was to evaluate the significance of low-level minimal/measurable residual disease (MRD) during early consolidation treatment in adult BCR-ABL1-negative acute lymphoblastic leukaemia. The MRD load was monitored by immunoglobulin/T-cell receptor rearrangements and assessed as negative [complete MRD response (CMR)], positive non-quantifiable (MRDnq) and positive quantifiable (MRDq). MRDnq before the first and second consolidation blocks had a comparable negative effect on survival as MRDq. The 5-year overall survival for CMR, MRDnq and MRDq at week 11 was 74·0%, 42·3% and 35·0% respectively. No central nervous system infiltration and MRD at week 11 were independent prognostic factors for survival on multivariate analysis (hazard ratios 0·32 and 2·25).
(© 2021 British Society for Haematology and John Wiley & Sons Ltd.)
Databáze: MEDLINE
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