Association between Hypertriglyceridemia and Disease Severity in Visceral Leishmaniasis.

Autor:	Varela MG; Immunology and Molecular Biology Laboratory, University Hospital, Federal University of Sergipe (HU-UFS), Aracaju, Sergipe, Brazil.; Endocrinology Service from the University Hospital/EBSERH, Federal University of Sergipe, Aracaju, Sergipe, Brazil.; Heath Science Graduate Program, Aracaju, Brazil., de Oliveira Bezerra M; Immunology and Molecular Biology Laboratory, University Hospital, Federal University of Sergipe (HU-UFS), Aracaju, Sergipe, Brazil., Santana FV; Immunology and Molecular Biology Laboratory, University Hospital, Federal University of Sergipe (HU-UFS), Aracaju, Sergipe, Brazil., Gomes MC; Immunology and Molecular Biology Laboratory, University Hospital, Federal University of Sergipe (HU-UFS), Aracaju, Sergipe, Brazil., de Jesus Almeida PR; Universidade Federal de Minas Gerais (UFMG), Faculdade de Medicina, Belo Horizonte, Minas Gerais, Brazil., Silveira da Cruz G; Heath Science Graduate Program, Aracaju, Brazil.; Hematology Service, University Hospital, Federal University of Sergipe (HU-UFS), Aracaju, Sergipe, Brazil., de Melo EV; Pediatric Clinic, University Hospital, Federal University of Sergipe (HU-UFS), Aracaju, Sergipe, Brazil., de Oliveira Costa PR; Infectious Disease Clinic, University Hospital, Federal University of Sergipe (HU-UFS), Aracaju, Sergipe, Brazil., de Oliveira FA; Immunology and Molecular Biology Laboratory, University Hospital, Federal University of Sergipe (HU-UFS), Aracaju, Sergipe, Brazil., de Jesus AR; Immunology and Molecular Biology Laboratory, University Hospital, Federal University of Sergipe (HU-UFS), Aracaju, Sergipe, Brazil.; Heath Science Graduate Program, Aracaju, Brazil.; Immunology Investigative Institute, INCT, CNPq, São Paulo, Brazil., de Almeida RP; Immunology and Molecular Biology Laboratory, University Hospital, Federal University of Sergipe (HU-UFS), Aracaju, Sergipe, Brazil.; Heath Science Graduate Program, Aracaju, Brazil.; Immunology Investigative Institute, INCT, CNPq, São Paulo, Brazil.
Jazyk:	angličtina
Zdroj:	The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 2021 Nov 22; Vol. 106 (2), pp. 643-647. Date of Electronic Publication: 2021 Nov 22.
DOI:	10.4269/ajtmh.21-0260
Abstrakt:	Visceral leishmaniasis (VL) is a tropical disease endemic to Brazil. The clinical manifestations of the infection range from asymptomatic to severe. In VL, changes in lipid metabolism, such as hypocholesterolemia and hypertriglyceridemia, occur that are believed to be related to its progression and severity. This study investigated the associations between serum levels of cholesterol, triglycerides, and lipoproteins (high-density lipoprotein, low-density lipoprotein, and very low-density lipoprotein) with clinical and hematological parameters that predict severity in a case series of 83 VL patients. Severely ill patients had higher mean serum triglyceride levels than non-severely ill patients. There was a significant positive correlation between disease severity score and serum triglyceride levels, very low-density lipoprotein, international normalized ratio for prothrombin time test, total bilirubin, and age. An inverse correlation was detected between the disease severity score and mean platelet and neutrophil counts. Hypertriglyceridemia can be a prognostic indicator of severity in patients diagnosed with VL.
Databáze:	MEDLINE
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