Nanoparticles-reinforced poly-l-lactic acid composite materials as bioresorbable scaffold candidates for coronary stents: Insights from mechanical and finite element analysis.

Autor: Toong DWY; School of Materials Science and Engineering, Nanyang Technological University, Nanyang Avenue, 639798, Singapore., Ng JCK; National Heart Research Institute Singapore, National Heart Centre Singapore, 5 Hospital Drive, 169609, Singapore; Department of Biomedical Engineering, National University of Singapore, 4 Engineering Drive 3, 117583, Singapore., Cui F; Institute of High Performance Computing, A*STAR, 1 Fusionopolis way, 138632, Singapore., Leo HL; Department of Biomedical Engineering, National University of Singapore, 4 Engineering Drive 3, 117583, Singapore., Zhong L; National Heart Research Institute Singapore, National Heart Centre Singapore, 5 Hospital Drive, 169609, Singapore; Duke-NUS Medical School, 8 College Road, 169857, Singapore., Lian SS; Department of Biomedical Engineering, National University of Singapore, 4 Engineering Drive 3, 117583, Singapore., Venkatraman S; Department of Material Science Engineering, National University of Singapore, 9 Engineering Drive 1, 117575, Singapore., Tan LP; School of Materials Science and Engineering, Nanyang Technological University, Nanyang Avenue, 639798, Singapore., Huang YY; School of Materials Science and Engineering, Nanyang Technological University, Nanyang Avenue, 639798, Singapore. Electronic address: yingyinghuang@ntu.edu.sg., Ang HY; National Heart Research Institute Singapore, National Heart Centre Singapore, 5 Hospital Drive, 169609, Singapore; Department of Biomedical Engineering, National University of Singapore, 4 Engineering Drive 3, 117583, Singapore; Duke-NUS Medical School, 8 College Road, 169857, Singapore. Electronic address: gmsahy@nus.edu.sg.
Jazyk: angličtina
Zdroj: Journal of the mechanical behavior of biomedical materials [J Mech Behav Biomed Mater] 2022 Jan; Vol. 125, pp. 104977. Date of Electronic Publication: 2021 Nov 17.
DOI: 10.1016/j.jmbbm.2021.104977
Abstrakt: Current generation of bioresorbable coronary scaffolds (BRS) posed thrombogenicity and deployment issues owing to its thick struts and overall profile. To this end, we hypothesize that the use of nanocomposite materials is able to provide improved material properties and sufficient radial strength for the intended application even at reduced strut thickness. The nanocomposite formulations of tantalum dioxide (Ta 2 O 5 ), L-lactide functionalized (LA)-Ta 2 O 5 , hydroxyapatite (HA) and LA-HA with poly-l-lactic acid (PLLA) were evaluated in this study. Results showed that tensile modulus and strength were enhanced with non-functionalized nanofillers up until 15 wt% loading, whereas ductility was compromised. On the other hand, functionalized nanofillers/PLLA exhibited improved nanofiller dispersion which resulted higher tensile modulus, strength, and ductility. Selected nanocomposite formulations were evaluated using finite element analysis (FEA) of a stent with varying strut thickness (80, 100 and 150 μm). FEA data has shown that nanocomposite BRS with thinner struts (80-100 μm) made with 15 wt% LA-Ta 2 O 5 /PLLA and 10 wt% LA-HA/PLLA have increased radial strength, stiffness and reduced recoil compared to PLLA BRS at 150 μm. The reduced strut thickness can potentially mitigate issues such as scaffold thrombosis and promote re-endothelialisation of the vessel.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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