Incidence and Outcome of Acute Kidney Injury in Patients Hospitalized With Coronavirus Disease-19 at a Tertiary Care Medical Center in Saudi Arabia.

Autor:	Farooqui MA; Division of Nephrology, Department of Medicine, King Saud Bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City Riyadh, Riyadh, SAU.; Department of Nephrology, King Abdulaziz Medical City Riyadh, Riyadh, SAU.; Department of Medicine, King Abdullah International Medical Research Center, Riyadh, SAU., Almegren A; Department of Nephrology, King Saud Bin Abdulaziz University for Health Sciences College of Medicine, Riyadh, SAU., Binrushud SR; Department of Nephrology, King Saud Bin Abdulaziz University for Health Sciences College of Medicine, Riyadh, SAU., Alnuwaiser FA; Department of Nephrology, King Saud Bin Abdulaziz University for Health Sciences College of Medicine, Riyadh, SAU., Almegren NM; Department of Nephrology, King Saud Bin Abdulaziz University for Health Sciences College of Medicine, Riyadh, SAU., Alhamied NA; Department of Nephrology, King Saud Bin Abdulaziz University for Health Sciences College of Medicine, Riyadh, SAU., Aloraifi EA; Department of Nephrology, King Saud Bin Abdulaziz University for Health Sciences College of Medicine, Riyadh, SAU., Alothman AM; Department of Nephrology, King Saud Bin Abdulaziz University for Health Sciences College of Medicine, Riyadh, SAU., Aldafas MA; Department of Nephrology, King Saud Bin Abdulaziz University for Health Sciences College of Pharmacy, Riyadh, SAU., Ardah HI; Department of Biostatistics and Epidemiology, King Abdullah International Medical Research Center, Riyadh, SAU.; Department of Statistics, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, SAU.; Department of Biostatistics, King Abdulaziz Medical City Riyadh, Riyadh, SAU., Alhejaili FF; Department of Nephrology, King Saud Bin Abdulaziz University for Health Sciences College of Medicine, Riyadh, SAU.; Department of Nephrology, King Abdulaziz Medical City Riyadh, Riyadh, SAU.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2021 Oct 20; Vol. 13 (10), pp. e18927. Date of Electronic Publication: 2021 Oct 20 (Print Publication: 2021).
DOI:	10.7759/cureus.18927
Abstrakt:	Introduction The systemic acute respiratory syndrome coronavirus (SARS-CoV-2) has been associated with acute kidney injury (AKI). We retrospectively studied the incidence and outcome of AKI in patients hospitalized with COVID-19 at King Abdulaziz Medical City (KAMC) Riyadh, Kingdom of Saudi Arabia. Methods A retrospective cohort study was conducted after ethical approval from the institutional review board of King Abdullah International Medical Research Center (KAIMRC). Subjects were identified by Data Management Office of KAIMRC. The data were extracted from electronic medical records using a customized data collection sheet. The study included all adult patients (>18 years) who tested positive for COVID-19 by polymerase chain reaction and were admitted at KAMC from March 2020 until the end of September 2020. Patients with a history of end-stage kidney diseases and patients where adequate data were not available to establish diagnosis of AKI were excluded. Patient demographics, comorbid conditions, medications, use of mechanical ventilation, and 30-day mortality were recorded. Results During the study period (01 March 2020 to 30 September 2020) 1293 patients were hospitalized at KAMC with the diagnosis of COVID-19. After excluding the patients who met the exclusion criteria, data were collected for 1025 patients [male 582 (56.8%); female 443 (43.2%)]. On univariate analysis, increasing age, male gender, use of angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, diuretics, and vasopressors, presence of chronic kidney disease, coronary artery disease, chronic obstructive pulmonary disease, dyslipidemia, diabetes mellitus, heart failure, and hypertension, kidney transplant status, and mechanical ventilation were associated with development of AKI. On multivariate logistic regression analysis, independent predictors of AKI were restricted to increasing age, presence of chronic kidney disease, hypertension, kidney transplant status, use of vasopressors, and mechanical ventilation. For patients who developed AKI, 30-day mortality was 40.7% compared to 3.7% for those who did not develop AKI (p<0.001). Conclusion For hospitalized patients with COVID-19, we observed an incidence of AKI of 36%. Increasing age, presence of chronic kidney disease and hypertension, kidney transplant status, use of vasopressors, and mechanical ventilation were independently associated with development of AKI. Presence of AKI was associated with higher 30-day mortality (40.7% vs 3.7%). Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2021, Farooqui et al.)
Databáze:	MEDLINE
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