Multimodal characterization of Yucatan minipig behavior and physiology through maturation.

Autor: Netzley AH; Department of Biomedical Engineering, Michigan State University, East Lansing, MI, USA.; Neuroengineering Division, The Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA., Hunt RD; Department of Biomedical Engineering, Michigan State University, East Lansing, MI, USA.; Neuroengineering Division, The Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA., Franco-Arellano J; Department of Biomedical Engineering, Michigan State University, East Lansing, MI, USA.; Neuroengineering Division, The Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA., Arnold N; Department of Mechanical Engineering, Michigan State University, East Lansing, MI, USA., Vazquez AI; Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI, USA., Munoz KA; Department of Small Animal Clinical Sciences, Michigan State University College of Veterinary Medicine, Michigan State University, East Lansing, MI, USA., Colbath AC; Department of Large Animal Clinical Sciences, Michigan State University College of Veterinary Medicine, East Lansing, MI, USA., Bush TR; Department of Mechanical Engineering, Michigan State University, East Lansing, MI, USA., Pelled G; Department of Biomedical Engineering, Michigan State University, East Lansing, MI, USA. pelledga@msu.edu.; Neuroengineering Division, The Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA. pelledga@msu.edu.; Department of Radiology, Michigan State University, East Lansing, MI, USA. pelledga@msu.edu.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2021 Nov 22; Vol. 11 (1), pp. 22688. Date of Electronic Publication: 2021 Nov 22.
DOI: 10.1038/s41598-021-00782-w
Abstrakt: Brain injuries induced by external forces are particularly challenging to model experimentally. In recent decades, the domestic pig has been gaining popularity as a highly relevant animal model to address the pathophysiological mechanisms and the biomechanics associated with head injuries. Understanding cognitive, motor, and sensory aspects of pig behavior throughout development is crucial for evaluating cognitive and motor deficits after injury. We have developed a comprehensive battery of tests to characterize the behavior and physiological function of the Yucatan minipig throughout maturation. Behavioral testing included assessments of learning and memory, executive functions, circadian rhythms, gait analysis, and level of motor activity. We applied traditional behavioral apparatus and analysis methods, as well as state-of-the-art sensor technologies to report on motion and activity, and artificial intelligent approaches to analyze behavior. We studied pigs from 16 weeks old through sexual maturity at 35 weeks old. The results show multidimensional characterization of minipig behavior, and how it develops and changes with age. This animal model may capitulate the biomechanical consideration and phenotype of head injuries in the developing brain and can drive forward the field of understanding pathophysiological mechanisms and developing new therapies to accelerate recovery in children who have suffered head trauma.
(© 2021. The Author(s).)
Databáze: MEDLINE
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