Folate intake and ovarian reserve among women attending a fertility center.

Autor: Kadir M; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia., Hood RB; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia., Mínguez-Alarcón L; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts., Maldonado-Cárceles AB; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts., Ford JB; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts., Souter I; Massachusetts General Hospital Fertility Center and Harvard Medical School, Boston, Massachusetts., Chavarro JE; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts., Gaskins AJ; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia. Electronic address: audrey.jane.gaskins@emory.edu.
Jazyk: angličtina
Zdroj: Fertility and sterility [Fertil Steril] 2022 Jan; Vol. 117 (1), pp. 171-180. Date of Electronic Publication: 2021 Nov 19.
DOI: 10.1016/j.fertnstert.2021.09.037
Abstrakt: Objective: To examine the association between dietary folate intake and antral follicle count (AFC) among women seeing treatment for infertility.
Design: Cohort study.
Setting: Academic fertility center.
Patients: A total of 552 women attending the Massachusetts General Hospital Fertility Center (2007-2019) who participated in the Environment and Reproductive Health Study.
Interventions: None. Folate intake was measured with a validated food frequency questionnaire at study entry. Multivariable Poisson regression models with robust standard errors were used to estimate the association of folate intake with AFC adjusting for calorie intake, age, body mass index, physical activity, education, smoking status, year of AFC, and intakes of vitamin B 12 , iron, and vitamin D. Nonlinearity was assessed with restricted cubic splines.
Main Outcome Measure: AFC as measured by transvaginal ultrasonography as part of routine care.
Results: Among the 552 women (median age, 35.0 years; median folate intake, 1,005 μg/d), total and supplemental folate intake had a significant nonlinear relationship with AFC. There was a positive linear association with AFC up to approximately 1,200 μg/d for total folate intake and up to 800 μg/d for supplemental folate intake; however, there was no additional benefit of higher folate intakes. The magnitude of the association was modest; for example, the predicted adjusted difference in AFC between a woman consuming 400 vs. 800 μg/d of supplemental folate was approximately 1.5 follicles.
Conclusion: Higher intake of folate, particularly from supplements, was associated with modestly higher ovarian reserve as measured by AFC among women attending a fertility center.
Clinical Trial Registration Number: This trial was registered at clinicaltrials.gov as NCT00011713.
(Copyright © 2021 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: