Is there an association of genetic polymorphisms of the catechol-O-methyltransferase gene (rs165656 and rs174675) and the 5-hydroxytryptamine receptor 2A gene (rs4941573 and rs6313) with sleep bruxism in individuals with obstructive sleep apnea?

Autor: Duarte J; Brazilian Center for Evidence-Based Research (COBE), Federal University of Santa Catarina, Florianópolis, Brazil; Department of Dentistry, Federal University of Santa Catarina, Florianópolis, Brazil. Electronic address: joyceduarteortodtm@gmail.com., Pauletto P; Brazilian Center for Evidence-Based Research (COBE), Federal University of Santa Catarina, Florianópolis, Brazil; Department of Dentistry, Federal University of Santa Catarina, Florianópolis, Brazil., Polmann H; Brazilian Center for Evidence-Based Research (COBE), Federal University of Santa Catarina, Florianópolis, Brazil; Department of Dentistry, Federal University of Santa Catarina, Florianópolis, Brazil., Réus JC; Brazilian Center for Evidence-Based Research (COBE), Federal University of Santa Catarina, Florianópolis, Brazil; Department of Dentistry, Federal University of Santa Catarina, Florianópolis, Brazil., de Souza JF; Department of Stomatology, School of Dentistry, Federal University of Paraná, Curitiba, Brazil., Gaio DC; School of Health Sciences, Positivo University, Curitiba, Paraná, Brazil., Brancher JA; School of Health Sciences, Positivo University, Curitiba, Paraná, Brazil., Vieira A; Graduate Program in Biotechnology Applied to Child and Adolescent Health - Pequeno Príncipe College, Pelé Research Institute, Curitiba, Paraná, Brazil., Machado-Souza C; Graduate Program in Biotechnology Applied to Child and Adolescent Health - Pequeno Príncipe College, Pelé Research Institute, Curitiba, Paraná, Brazil., de Souza Melo G; Brazilian Center for Evidence-Based Research (COBE), Federal University of Santa Catarina, Florianópolis, Brazil; Department of Dentistry, Federal University of Santa Catarina, Florianópolis, Brazil., Maia IS; Baía Sul Research Institute, Florianópolis, Santa Catarina, Brazil., De Luca Canto G; Brazilian Center for Evidence-Based Research (COBE), Federal University of Santa Catarina, Florianópolis, Brazil; Department of Dentistry, Federal University of Santa Catarina, Florianópolis, Brazil.
Jazyk: angličtina
Zdroj: Archives of oral biology [Arch Oral Biol] 2022 Jan; Vol. 133, pp. 105315. Date of Electronic Publication: 2021 Nov 17.
DOI: 10.1016/j.archoralbio.2021.105315
Abstrakt: Objective: To evaluate the association of single-nucleotide polymorphisms within the catechol-O-methyltransferase and 5-hydroxytryptamine receptor 2A genes with sleep bruxism in individuals diagnosed with obstructive sleep apnea.
Design: Sixty-nine individuals with suspected sleep-related problems were evaluated by polysomnography, following the recommendations of the American Academy of Sleep Medicine. Deoxyribonucleic acid (DNA) samples were collected only from 48 of the study participants because of missing polysomnographic data. DNA samples were collected and two single-nucleotide polymorphisms in the 5-hydroxytryptamine receptor 2A encoding HTR2A gene (rs4941573 and rs6313) and two in the catechol-O-methyltransferase gene (rs165656 and rs174675) were selected to be genotyped using real-time polymerase chain reaction. The association between sleep bruxism and genetic polymorphisms was investigated by recessive and dominant models. Association analyses were performed using a 95% confidence interval and the level of statistical significance was p < 0.05.
Results: From the 69 study participants, 48 were included in the polymorphism analysis and sleep bruxism was present in 35.4%. No significant differences were observed in the dominant and recessive models (p > 0.05). Haplotype and diplotype analyses revealed the predicted four haplotypes and two diplotypes were not associated with sleep bruxism.
Conclusion: Polymorphisms rs174675 and rs165656 in the catechol-O-methyltransferase gene and rs4941573 and rs6313 in the 5-hydroxytryptamine receptor 2A gene were not significantly associated with sleep bruxism in individuals with obstructive sleep apnea.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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