| Autor: |
Haghpanah S; Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran., Hosseini-Bensenjan M; Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran., Sayadi M; Cardiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran., Karimi M; Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran., de Sanctis V; Pediatric and Adolescent Outpatient Clinic, Quisisana Hospital, Ferrara, Italy., Ramzi M; Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran., Mousavi MR; Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. |
| Jazyk: |
angličtina |
| Zdroj: |
Hemoglobin [Hemoglobin] 2021 Sep; Vol. 45 (5), pp. 275-286. Date of Electronic Publication: 2021 Nov 21. |
| DOI: |
10.1080/03630269.2021.2003382 |
| Abstrakt: |
As a cause of chronic blood transfusions, iron overload is an important issue in β-thalassemia (β-thal) patients that leads to multiple organ dysfunctions. This is an updated meta-analysis conducted to summarize the existing evidence of the prevalence of hypothyroidism (HT) among patients with transfusion-dependent (TDT) and non transfusion-dependent β-thal (NTDT) and for the first time we meta-analyzed the relationship between ferritin level and HT. This systematic review and meta-analysis were done according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist. We searched databases including Web of Science (ISI), Scopus, PubMed, Embase, and Scholar. The quality of the included studies was assessed based on the Newcastle-Ottawa scale (NOS) checklist. Meta-analysis was done using Stata statistical software. The pooled prevalence of total HT, subclinical HT, and overt HT among β-thal patients was 13.25 [95% confidence interval (95% CI): 10.29-16.21; 11.84, 95% CI: 8.43-15.25 and 12.46, 95% CI: 1.05-23.87], respectively. The prevalence of total HT was 16.22% (95% CI: 12.36-20.08) in TDT and 7.22% (95% CI: 3.66-10.78) in NTDT patients. Serum ferritin (SF) levels were significantly lower in euthyroid compared to hypothyroid patients [standard mean difference (SMD) -2.15 (95% CI: -3.08, -1.21, p value <0.001]. The prevalence of HT was higher in TDT compared to NTDT patients. Moreover, our results showed a significant association of high serum ferritin (SF) levels with hypothyroidism in β-thal patients. Both of these findings highlight the importance of prevention measures and timely diagnosis and management of iron overload in β-thal patients. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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