Nimotuzumab for COVID-19: case series.
| Autor: | Abdo Cuza AA; Intensive Care Unit. Medical & Surgical Research Center (CIMEQ), Havana, Cuba., Ávila JP; Intensive Care Unit. Medical & Surgical Research Center (CIMEQ), Havana, Cuba., Martínez RM; Intensive Care Unit. Medical & Surgical Research Center (CIMEQ), Havana, Cuba., González JJ; Radiology Department. Medical & Surgical Research Center (CIMEQ), Havana, Cuba., Aspuro GP; Intensive Care Unit. Medical & Surgical Research Center (CIMEQ), Havana, Cuba., Gutiérrez Martínez JA; Intensive Care Unit. Medical & Surgical Research Center (CIMEQ), Havana, Cuba., Suzarte MR; Clinical Research Direction. Center of Molecular Immunology (CIM), Havana, Cuba., Hernández DS; Clinical Research Direction. Center of Molecular Immunology (CIM), Havana, Cuba., Añé-Kouri AL; Clinical Research Direction. Center of Molecular Immunology (CIM), Havana, Cuba., Ramos TC; Clinical Research Direction. Center of Molecular Immunology (CIM), Havana, Cuba. |
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| Jazyk: | angličtina |
| Zdroj: | Immunotherapy [Immunotherapy] 2021 Nov 22. Date of Electronic Publication: 2021 Nov 22. |
| DOI: | 10.2217/imt-2021-0269 |
| Abstrakt: | Background: In COVID-19, EGFR production is upregulated in the alveolar epithelial cells. EGFR overexpression further activates STAT-3 and increases lung pathology. The EGFR pathway is also one of the major nodes in pulmonary fibrosis. Methods: Nimotuzumab, a humanized anti-EGFR antibody, was used to treat three patients with severe or moderate COVID-19. The antibody was administered in combination with other drugs included in the national COVID-19 protocol. Results: Nimotuzumab was well tolerated. IL-6 decreased from the first antibody infusion. Clinical symptoms significantly improved after nimotuzumab administration, and the CT scans at discharge showed major resolution of the lung lesions and no signs of fibrosis. Conclusion: Safe anti-EGFR antibodies like nimotuzumab may modulate COVID-19-associated hyperinflammation and prevent fibrosis. Clinical Trial Registration: RPCEC00000369 (RPCEC rpcec.sld.cu). |
| Databáze: | MEDLINE |
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