Serum neurofilament light as biomarker of seizure-related neuronal injury in status epilepticus.

Autor: Giovannini G; Neurology Unit, Ospedale Civile Baggiovara Hospital, University Hospital, Modena, Italy.; Department of Biomedical, Metabolic, and Neural Science, University of Modena and Reggio Emilia, Modena, Italy.; PhD Program in Clinical and Experimental Medicine, University of Modena and Reggio Emilia, Modena, Italy., Bedin R; Department of Biomedical, Metabolic, and Neural Science, University of Modena and Reggio Emilia, Modena, Italy., Ferraro D; Neurology Unit, Ospedale Civile Baggiovara Hospital, University Hospital, Modena, Italy.; Department of Biomedical, Metabolic, and Neural Science, University of Modena and Reggio Emilia, Modena, Italy., Vaudano AE; Neurology Unit, Ospedale Civile Baggiovara Hospital, University Hospital, Modena, Italy., Mandrioli J; Neurology Unit, Ospedale Civile Baggiovara Hospital, University Hospital, Modena, Italy.; Department of Biomedical, Metabolic, and Neural Science, University of Modena and Reggio Emilia, Modena, Italy., Meletti S; Neurology Unit, Ospedale Civile Baggiovara Hospital, University Hospital, Modena, Italy.; Department of Biomedical, Metabolic, and Neural Science, University of Modena and Reggio Emilia, Modena, Italy.
Jazyk: angličtina
Zdroj: Epilepsia [Epilepsia] 2022 Jan; Vol. 63 (1), pp. e23-e29. Date of Electronic Publication: 2021 Nov 21.
DOI: 10.1111/epi.17132
Abstrakt: Biomarkers of neuronal damage in status epilepticus (SE) would be of great relevance for clinical and research purposes. In a retrospective cross-sectional study, serum neurofilament light chain (NfL) levels were measured in patients with SE (30 subjects), patients with drug-resistant epilepsy (30 subjects), and healthy controls (30 subjects). Serum NfL levels were higher in patients with SE (median = 26.15 pg/ml) compared to both epilepsy patients (median = 7.35 pg/ml) and healthy controls (median = 6.81 pg/ml; p < .001). In patients with SE, serum NfL levels showed a high correlation with cerebrospinal fluid (CSF) NfL (τ = .68, p < .001) as well as with CSF total tau (t-tau) levels (τ = .627, p < .001); they were higher in SE lasting >24 h (p = .013), in refractory/superrefractory SE (p = .004), and in patients who died within 30 days or who presented a worsening of clinical conditions (p = .001). Values of >28.8 pg/ml predicted 30-day clinical worsening or death (odds ratio [OR] = 10.83, 95% confidence interval [CI] = 1.96-59.83, p = .006) and SE refractoriness (OR = 9.33, 95% CI = 1.51-57.65, p = .016). In conclusion, serum NfL levels are increased in SE and correlate with SE treatment response, duration, and outcomes, therefore representing a promising biomarker of seizure-related neuronal damage.
(© 2021 The Authors. Epilepsia published by Wiley Periodicals LLC on behalf of International League Against Epilepsy.)
Databáze: MEDLINE
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