Inherited Tolerance in Cattle to the Apicomplexan Protozoan Theileria parva is Associated with Decreased Proliferation of Parasite-Infected Lymphocytes.

Autor:	Latre de Late P; International Livestock Research Institute (ILRI), Nairobi, Kenya.; Centre for Tropical Livestock Genetics and Health, Nairobi, Kenya., Cook EAJ; International Livestock Research Institute (ILRI), Nairobi, Kenya.; Centre for Tropical Livestock Genetics and Health, Nairobi, Kenya., Wragg D; The Roslin Institute, University of Edinburgh, Edinburgh, United Kingdom.; Centre for Tropical Livestock Genetics and Health, Edinburgh, United Kingdom., Poole EJ; International Livestock Research Institute (ILRI), Nairobi, Kenya., Ndambuki G; International Livestock Research Institute (ILRI), Nairobi, Kenya.; Centre for Tropical Livestock Genetics and Health, Nairobi, Kenya., Miyunga AA; International Livestock Research Institute (ILRI), Nairobi, Kenya.; Centre for Tropical Livestock Genetics and Health, Nairobi, Kenya., Chepkwony MC; International Livestock Research Institute (ILRI), Nairobi, Kenya.; Centre for Tropical Livestock Genetics and Health, Nairobi, Kenya., Mwaura S; International Livestock Research Institute (ILRI), Nairobi, Kenya., Ndiwa N; International Livestock Research Institute (ILRI), Nairobi, Kenya., Prettejohn G; Ol Pejeta Conservancy, Nanyuki, Kenya., Sitt T; International Livestock Research Institute (ILRI), Nairobi, Kenya., Van Aardt R; Ol Pejeta Conservancy, Nanyuki, Kenya., Morrison WI; The Roslin Institute, University of Edinburgh, Edinburgh, United Kingdom., Prendergast JGD; The Roslin Institute, University of Edinburgh, Edinburgh, United Kingdom.; Centre for Tropical Livestock Genetics and Health, Edinburgh, United Kingdom., Toye P; International Livestock Research Institute (ILRI), Nairobi, Kenya.; Centre for Tropical Livestock Genetics and Health, Nairobi, Kenya.
Jazyk:	angličtina
Zdroj:	Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2021 Nov 05; Vol. 11, pp. 751671. Date of Electronic Publication: 2021 Nov 05 (Print Publication: 2021).
DOI:	10.3389/fcimb.2021.751671
Abstrakt:	Theileria parva is the causative agent of East Coast fever and Corridor disease, which are fatal, economically important diseases of cattle in eastern, central and southern Africa. Improved methods of control of the diseases are urgently required. The parasite transforms host lymphocytes, resulting in a rapid, clonal expansion of infected cells. Resistance to the disease has long been reported in cattle from T. parva -endemic areas. We reveal here that first- and second-generation descendants of a single Bos indicus bull survived severe challenge with T. parva , (overall survival rate 57.3% compared to 8.7% for unrelated animals) in a series of five field studies. Tolerant cattle displayed a delayed and less severe parasitosis and febrile response than unrelated animals. The in vitro proliferation of cells from surviving cattle was much reduced compared to those from animals that succumbed to infection. Additionally, some pro-inflammatory cytokines such as IL1β, IL6, TNFα or TGFβ which are usually strongly expressed in susceptible animals and are known to regulate cell growth or motility, remain low in tolerant animals. This correlates with the reduced proliferation and less severe clinical reactions observed in tolerant cattle. The results show for the first time that the inherited tolerance to T. parva is associated with decreased proliferation of infected lymphocytes. The results are discussed in terms of whether the reduced proliferation is the result of a perturbation of the transformation mechanism induced in infected cells or is due to an innate immune response present in the tolerant cattle. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Latre de Late, Cook, Wragg, Poole, Ndambuki, Miyunga, Chepkwony, Mwaura, Ndiwa, Prettejohn, Sitt, Van Aardt, Morrison, Prendergast and Toye.)
Databáze:	MEDLINE
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