Post-Hemorrhagic Hydrocephalus and Outcomes Amongst Neonates With Intraventricular Hemorrhage: A Systematic Review and Pooled Analysis.

Autor:	Pinto C; Public Health, Icahn School of Medicine at Mount Sinai, New York, USA., Malik P; Pathology, Montefiore Medical Center, Wakefield Campus, Bronx, USA.; Public Health, Icahn School of Medicine at Mount Sinai, New York, USA., Desai R; Internal Medicine, University of North Carolina Cardiology at Nash, Rocky Mount, USA., Shelar V; Internal Medicine, Saratov State Medical University, Saratov, RUS., Bekina-Sreenivasan D; Pediatric Medicine, Tyumen State Medical University, Tyumen, RUS., Satnarine TA; Neonatal Intensive Care Unit, Port of Spain General Hospital, Port of Spain, TTO., Lavado LK; Nursing, Rutgers School of Nursing, Newark, USA., Singla R; Pediatric Neurology, Children's Hospital of Michigan, Detroit, USA., Chavda D; Pediatric Neurology, State University of New York Downstate Medical Center, Brooklyn, USA., Kaul S; Pediatric Neurology, Mercyone North Iowa, Mason City, USA., Datta S; Neurology, NYU Langone Health, New York, USA., Shah S; Neurology, Stormont Vail Health, Topeka, USA., Patel UK; Neurology and Public Health, Icahn School of Medicine at Mount Sinai, New York, USA.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2021 Oct 18; Vol. 13 (10), pp. e18877. Date of Electronic Publication: 2021 Oct 18 (Print Publication: 2021).
DOI:	10.7759/cureus.18877
Abstrakt:	Introduction Intraventricular hemorrhage (IVH) is a common cause of morbidity and mortality in preterm neonates. IVH leads to complications such as posthemorrhagic hydrocephalus (PHH), which commonly occurs in neonates with a more severe degree of IVH. Hence, we aimed to evaluate the characteristics and outcomes of PHH in neonates with IVH. Methods We performed a systematic review of cases reported from January 1978 to December 2020 through the PubMed database, using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and the keywords 'intraventricular hemorrhage,' 'cerebral intraventricular hemorrhage,' and 'newborn.' A total of 79 articles were considered for analysis, and data on neonatal and maternal characteristics and outcomes were collected. The analysis was performed by using the χ2 test, Wilcoxon rank-sum test, and multivariate logistic regression model. Results We analyzed a total of 101 IVH cases, 54.5% were male and 62.4% preterm. Thirteen point nine percent (13.9%) presented with grade I, 35.6% grade II, and grade III respectively, and 8% grade IV IVH. Among the 59 (58.4%) neonates with PHH, 33.6% had resolved PHH and 24.8% had unresolved. In adjusted regression analysis, we found that neonates with resolved PHH have lower odds of having neurodevelopmental delay (OR:0.15, 95%CI:0.03-0.74; p=0.02) and death (OR:0.9;95%CI:0.01-0.99; p=0.049) as compared to unresolved PHH. Conclusion Our study showed that neonates with resolved PHH have a statistically significant lower risk of neurodevelopmental delay (NDD) and mortality. Future studies should be planned to evaluate the role of treatment and its effect on outcomes in IVH neonates with PHH as a complication. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2021, Pinto et al.)
Databáze:	MEDLINE
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