Vestibular Morphological Asymmetry Associated With Motion Sickness Susceptibility.

Autor:	Harada T; Toyota Central R&D Labs, Inc., Tokyo, Japan., Sugawara T; Toyota Central R&D Labs, Inc., Tokyo, Japan., Ito T; Department of Otolaryngology-Head and Neck Surgery, Nara Medical University, Kashihara, Japan., Wada Y; Department of Otolaryngology-Head and Neck Surgery, Nara Medical University, Kashihara, Japan., Fukunaga M; Division of Cerebral Integration, Department of System Neuroscience, National Institute for Physiological Sciences, Okazaki, Japan., Sadato N; Division of Cerebral Integration, Department of System Neuroscience, National Institute for Physiological Sciences, Okazaki, Japan., Larroque SK; Coma Science Group, GIGA-Consciousness, GIGA Institute, University of Liège, Liege, Belgium., Demertzi A; Physiology of Cognition Research Lab, GIGA-Consciousness, GIGA Institute, University of Liège, Liege, Belgium., Laureys S; Coma Science Group, GIGA-Consciousness, GIGA Institute, University of Liège, Liege, Belgium., Sakai H; Toyota Central R&D Labs, Inc., Tokyo, Japan.
Jazyk:	angličtina
Zdroj:	Frontiers in neuroscience [Front Neurosci] 2021 Nov 04; Vol. 15, pp. 763040. Date of Electronic Publication: 2021 Nov 04 (Print Publication: 2021).
DOI:	10.3389/fnins.2021.763040
Abstrakt:	Sensory conflicts leading to motion sickness can occur not only between but also within sensory modalities. The vestibular organs are located in both left and right inner ears, and their misalignment can be a source of self-motion related sensory conflicts. In the current study, using inner ear magnetic resonance imaging, we examined whether morphological asymmetry of the bilateral vestibular organs was associated with motion sickness susceptibility. The results showed a larger position asymmetry of bilateral vestibular organs in individuals with high rather than low susceptibility. In addition, vestibular position asymmetry was associated with reciprocal interaction (negative resting state functional connectivity) between vestibular and visuocortical regions in lowly, but not highly, susceptible individuals. In conclusion, these findings suggest that vestibular morphological asymmetry can be a source of sensory conflicts in individuals with dysfunctional reciprocal visuo-vestibular interactions, a putative neural mechanism for resolving sensory conflicts. Competing Interests: TH, TS, and HS were employed by Toyota Central R&D Labs. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Harada, Sugawara, Ito, Wada, Fukunaga, Sadato, Larroque, Demertzi, Laureys and Sakai.)
Databáze:	MEDLINE
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