On no man's land: Subjective experiences during unresponsive and responsive sedative states induced by four different anesthetic agents.

Autor: Radek L; Turku PET Centre, Turku University Hospital and University of Turku, PO Box 52, FI-20521 Turku, Finland. Electronic address: liemra@utu.fi., Koskinen L; Department of Psychology and Speech-Language Pathology, and Turku Brain and Mind Center, University of Turku, FI-20014 Turun yliopisto, Finland., Sandman N; Department of Psychology and Speech-Language Pathology, and Turku Brain and Mind Center, University of Turku, FI-20014 Turun yliopisto, Finland., Laaksonen L; Turku PET Centre, Turku University Hospital and University of Turku, PO Box 52, FI-20521 Turku, Finland; Department of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital and University of Turku, PO Box 52, FI-20521 Turku, Finland., Kallionpää RE; Department of Psychology and Speech-Language Pathology, and Turku Brain and Mind Center, University of Turku, FI-20014 Turun yliopisto, Finland., Scheinin A; Turku PET Centre, Turku University Hospital and University of Turku, PO Box 52, FI-20521 Turku, Finland; Department of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital and University of Turku, PO Box 52, FI-20521 Turku, Finland., Rajala V; Department of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital and University of Turku, PO Box 52, FI-20521 Turku, Finland., Maksimow A; Department of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital and University of Turku, PO Box 52, FI-20521 Turku, Finland., Laitio T; Department of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital and University of Turku, PO Box 52, FI-20521 Turku, Finland., Revonsuo A; Department of Psychology and Speech-Language Pathology, and Turku Brain and Mind Center, University of Turku, FI-20014 Turun yliopisto, Finland; Department of Cognitive Neuroscience and Philosophy, School of Bioscience, University of Skövde, PO Box 408, 541 28 Skövde, Sweden., Scheinin H; Turku PET Centre, Turku University Hospital and University of Turku, PO Box 52, FI-20521 Turku, Finland; Department of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital and University of Turku, PO Box 52, FI-20521 Turku, Finland; Institute of Biomedicine and Unit of Clinical Pharmacology, University of Turku and Turku University Hospital, FI-20014 Turun yliopisto, Finland., Valli K; Department of Psychology and Speech-Language Pathology, and Turku Brain and Mind Center, University of Turku, FI-20014 Turun yliopisto, Finland; Department of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital and University of Turku, PO Box 52, FI-20521 Turku, Finland; Department of Cognitive Neuroscience and Philosophy, School of Bioscience, University of Skövde, PO Box 408, 541 28 Skövde, Sweden.
Jazyk: angličtina
Zdroj: Consciousness and cognition [Conscious Cogn] 2021 Nov; Vol. 96, pp. 103239. Date of Electronic Publication: 2021 Nov 18.
DOI: 10.1016/j.concog.2021.103239
Abstrakt: To understand how anesthetics with different molecular mechanisms affect consciousness, we explored subjective experiences recalled after responsive and unresponsive sedation induced with equisedative doses of dexmedetomidine, propofol, sevoflurane, and S-ketamine in healthy male participants (N = 140). The anesthetics were administered in experimental setting using target-controlled infusion or vapouriser for one hour. Interviews conducted after anesthetic administration revealed that 46.9% (n = 46) of arousable participants (n = 98) reported experiences, most frequently dreaming or memory incorporation of the setting. Participants receiving dexmedetomidine reported experiences most often while S-ketamine induced the most multimodal experiences. Responsiveness at the end of anesthetic administration did not affect the prevalence or content of reported experiences. These results demonstrate that subjective experiences during responsive and unresponsive sedation are common and anesthetic agents with different molecular mechanisms of action may have different effects on the prevalence and complexity of the experiences, albeit in the present sample the differences between drugs were minute.
(Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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