Impact of metallic coating on the retention of 225 Ac and its daugthers within core-shell nanocarriers.

Autor: Karpov TE; Granov Russian Research Center of Radiology & Surgical Technologies, Leningradskaya Street 70 Pesochny, St. Petersburg 197758, Russian Federation; Peter The Great St. Petersburg Polytechnic University, Polytechnicheskaya 29, St. Petersburg 195251, Russian Federation., Muslimov AR; Granov Russian Research Center of Radiology & Surgical Technologies, Leningradskaya Street 70 Pesochny, St. Petersburg 197758, Russian Federation; St. Petersburg Academic University, Khlopin St. 8/3, St. Petersburg 194021, Russian Federation; Peter The Great St. Petersburg Polytechnic University, Polytechnicheskaya 29, St. Petersburg 195251, Russian Federation., Antuganov DO; Granov Russian Research Center of Radiology & Surgical Technologies, Leningradskaya Street 70 Pesochny, St. Petersburg 197758, Russian Federation., Postovalova AS; Peter The Great St. Petersburg Polytechnic University, Polytechnicheskaya 29, St. Petersburg 195251, Russian Federation., Pavlov DA; Lobachevsky University, 23/3 Gagarin prospect, Nizhny Novgorod 603950, Russian Federation., Usov YV; Lobachevsky University, 23/3 Gagarin prospect, Nizhny Novgorod 603950, Russian Federation., Shatik SV; Granov Russian Research Center of Radiology & Surgical Technologies, Leningradskaya Street 70 Pesochny, St. Petersburg 197758, Russian Federation., Zyuzin MV; Granov Russian Research Center of Radiology & Surgical Technologies, Leningradskaya Street 70 Pesochny, St. Petersburg 197758, Russian Federation; School of Physics and Engineering, ITMO University, Lomonosova 9, St. Petersburg 191002, Russian Federation. Electronic address: mikhail.zyuzin@metalab.ifmo.ru., Timin AS; Granov Russian Research Center of Radiology & Surgical Technologies, Leningradskaya Street 70 Pesochny, St. Petersburg 197758, Russian Federation; Peter The Great St. Petersburg Polytechnic University, Polytechnicheskaya 29, St. Petersburg 195251, Russian Federation; Research School of Chemical and Biomedical Engineering, National Research Tomsk Polytechnic University, Lenin Avenue 30, Tomsk 634050, Russian Federation. Electronic address: a_timin@mail.ru.
Jazyk: angličtina
Zdroj: Journal of colloid and interface science [J Colloid Interface Sci] 2022 Feb 15; Vol. 608 (Pt 3), pp. 2571-2583. Date of Electronic Publication: 2021 Nov 02.
DOI: 10.1016/j.jcis.2021.10.187
Abstrakt: Currently, alpha-emitting radionuclide 225 Ac is one of the most promising isotopes in alpha therapy due to its high linear energy transfer during four sequential alpha decays. However, the main obstacle preventing the full introduction of 225 Ac into clinical practice is the lack of stable retention of radionuclides, leading to free circulation of toxic isotopes in the body. In this work, the surface of silica nanoparticles (SiO 2 NPs) has been modified with metallic shells composed of titanium dioxide (TiO 2 ) and gold (Au) nanostructures to improve the retention of 225 Ac and its decay products within the developed nanocarriers. In vitro and in vivo studies in healthy mice show that the metallic surface coating of SiO 2 NPs promotes an enhanced sequestering of radionuclides ( 225 Ac and its daughter isotopes) compared to non-modified SiO 2 NPs for a prolonged period of time. Histological analysis reveals that for the period of 3-10 d after the injections, the developed nanocarriers have no significant toxic effects in mice. At the same time, almost no accumulation of leaked radionuclides can be detected in non-target organs (e.g., in the kidneys). In contrast, non-modified carriers (SiO 2 NPs) demonstrate the release of free radionuclides, which are distributed over the whole animal body with the consequent morphological changes in the lung, liver and kidney tissues. These results highlight the potential of the developed nanocarriers to be utilized as radionuclide delivery systems and offer an insight into design rules for the fabrication of new nanotherapeutic agents.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2021 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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