The stoned age: Sex differences in the effects of adolescent cannabinoid exposure on prefrontal cortex structure and function in animal models.

Autor:	Ginder DE; Department of Psychology, Washington State University, Pullman, WA, United States., Wright HR; Department of Integrative Physiology and Neuroscience, Washington State University, Pullman, WA, United States., McLaughlin RJ; Department of Psychology, Washington State University, Pullman, WA, United States; Department of Integrative Physiology and Neuroscience, Washington State University, Pullman, WA, United States. Electronic address: ryan.mclaughlin@wsu.edu.
Jazyk:	angličtina
Zdroj:	International review of neurobiology [Int Rev Neurobiol] 2022; Vol. 161, pp. 121-145. Date of Electronic Publication: 2021 Aug 03.
DOI:	10.1016/bs.irn.2021.07.005
Abstrakt:	Cannabis is the most used drug during adolescence, which is a period of enhanced cortical plasticity and synaptic remodeling that supports behavioral, cognitive, and emotional maturity. In this chapter, we review preclinical studies indicating that adolescent exposure to cannabinoids has lasting effects on the morphology and synaptic organization of the prefrontal cortex and associated circuitry, which may lead to cognitive dysfunction later in life. Additionally, we reviewed sex differences in the effects of adolescent cannabinoid exposure with a focus on brain systems that support cognitive functioning. The body of evidence indicates enduring sex-specific effects in behavior and organization of corticolimbic circuitry, which appears to be influenced by species, strain, drug, route of administration, and window/pattern of drug exposure. Caution should be exercised when extrapolating these results to humans. Adopting models that more closely resemble human cannabis use will provide more translationally relevant data concerning the long-term effects of cannabis use on the adolescent brain. (Copyright © 2022 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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