Comprehension of skin cancer genetic risk feedback in primary care patients.

Autor: Khan E; Department of Psychiatry and Behavioral Sciences, Mount Sinai Beth Israel, 281 1st Avenue, New York, NY, 10003, USA. erva.khan@mountsinai.org., Kaphingst KA; Huntsman Cancer Institute and Department of Communication, University of Utah, Salt Lake City, UT, USA., Meyer White K; Department of Internal Medicine, University of New Mexico, Albuquerque, NM, USA., Sussman A; Department of Internal Medicine, University of New Mexico, Albuquerque, NM, USA., Guest D; Department of Internal Medicine, University of New Mexico, Albuquerque, NM, USA., Schofield E; Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Dailey YT; Department of Internal Medicine, University of New Mexico, Albuquerque, NM, USA., Robers E; Department of Internal Medicine, University of New Mexico, Albuquerque, NM, USA., Schwartz MR; Department of Internal Medicine, University of New Mexico, Albuquerque, NM, USA., Li Y; Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Buller D; Klein Buendel, Inc, Golden, CO, USA., Hunley K; Department of Internal Medicine, University of New Mexico, Albuquerque, NM, USA., Berwick M; Department of Internal Medicine, University of New Mexico, Albuquerque, NM, USA., Hay JL; Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Jazyk: angličtina
Zdroj: Journal of community genetics [J Community Genet] 2022 Feb; Vol. 13 (1), pp. 113-119. Date of Electronic Publication: 2021 Nov 19.
DOI: 10.1007/s12687-021-00566-9
Abstrakt: Few studies have examined comprehension and miscomprehension of genetic risk feedback for moderate-risk genes in the general population. We examined the prevalence and nature of accurate and inaccurate genetic risk feedback comprehension among those who received genetic testing for melanocortin-1-receptor (MC1R) gene variants that confer moderate melanoma risk. Participants (N = 145 Albuquerque, NM) were tested as part of a randomized controlled trial. Two weeks after receiving MC1R genetic risk feedback, participants answered open-ended questions regarding their reactions to the MC1R feedback report. Participants' comprehension of their feedback (average-risk or higher-risk for melanoma) was evaluated through qualitative analysis of open-ended responses. Most participants demonstrated comprehension of their feedback results (i.e., 63% of average-risk participants [ARPs]; 51% of higher-risk participants [HRPs]). Miscomprehension was evident in fewer participants (i.e., 16% of ARPs, 11% of HRPs). A few ARPs misunderstood the purpose of testing, whereas a few HRPs reported confusion about the meaning of their risk feedback. Some participants' responses to the open-ended questions were too ambiguous to ascertain comprehension or miscomprehension (i.e., 21% of ARPs, 38% of HRPs). Taken together, these findings suggest that genetic testing feedback for MC1R risk variants is largely comprehensible to general population participants. This study adds to the work examining comprehension and usage of common, moderate risk genetic information in public health contexts. However, to maximize the utility of genetic risk information in the general population, further research is needed to investigate and address areas where common genetic risk feedback misunderstandings occur.
(© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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