Free-Standing Nanofilm Electrode Arrays for Long-Term Stable Neural Interfacings.

Autor: Gao L; CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, China.; CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Neuroscience, Chinese Academy of Sciences, Shanghai, 200031, China.; University of Chinese Academy of Sciences, Beijing, 100049, China., Wang J; CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, China.; CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Neuroscience, Chinese Academy of Sciences, Shanghai, 200031, China., Zhao Y; State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body, College of Mechanical and Vehicle Engineering, Hunan University, Changsha, 410082, China., Li H; CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, China., Liu M; CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, China., Ding J; CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, China., Tian H; CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, China., Guan S; CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, China., Fang Y; CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, China.; CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Neuroscience, Chinese Academy of Sciences, Shanghai, 200031, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.
Jazyk: angličtina
Zdroj: Advanced materials (Deerfield Beach, Fla.) [Adv Mater] 2022 Feb; Vol. 34 (5), pp. e2107343. Date of Electronic Publication: 2021 Dec 14.
DOI: 10.1002/adma.202107343
Abstrakt: Flexible neural electrodes integrated on micrometer-thick polymer substrates offer important opportunities for improving the stability of neuronal activity recordings during cognitive processes. However, the bending stiffness of micrometer-thick polymer substrates is typically two orders of magnitude higher than that of nanofilm electrodes, making it a limiting factor in electrode-tissue interfacings. Here, this limitation is overcome by developing self-assembled nanofilm electrode arrays (NEAs) that consist of high-density, free-standing gold nanofilm electrodes. Chronically implanted NEAs can form intimate and innervated interfaces with neural tissue, enabling stable neuronal activity recordings across multiple brain regions over several months. As an application example, the activities of the same neuronal populations are tracked across odor discrimination reversal learning and it is illustrated how dorsal striatal neurons represent and update stimulus-outcome associations across multiple timescales. The results underscore the potential of free-standing nanoscale materials for interfacing biological systems over long terms.
(© 2021 Wiley-VCH GmbH.)
Databáze: MEDLINE
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