Organized Structure of Ventricular Fibrillation during Prolonged Heart Perfusion in Dogs.

Autor:	Guryanov MI; Professor, Department of Basic and Specific Medical Sciences, Faculty of Medicine; Saint Petersburg State University, 79 Universitetskaya Naberezhnaya, Saint Petersburg, 199034, Russia., Pusev RS; Associate Professor, Department of Informatics, Saint Petersburg School of Physics, Mathematics, and Computer Science; National Research University Higher School of Economics, 16 Soyuza Pechatnikov St., Saint Petersburg, 199008, Russia., Guryanova NM; PhD Student, Department of Pharmacology, Faculty of Medicine; Saint Petersburg State University, 79 Universitetskaya Naberezhnaya, Saint Petersburg, 199034, Russia., Kharitonova EA; Associate Professor, Department of Basic and Specific Medical Sciences, Faculty of Medicine; Saint Petersburg State University, 79 Universitetskaya Naberezhnaya, Saint Petersburg, 199034, Russia., Yablonsky PK; Professor, Director; Saint Petersburg Research Institute of Phthisiopulmonology, Ministry of Health the Russian Federation, 24 Ligovsky Avenue, Saint Petersburg, 191036, Russia; Head of the Department of Hospital Surgery; Saint Petersburg State University, 7-9 Universitetskaya Naberezhnaya, Saint Petersburg, 199034, Russia; Dean of the Faculty of Medicine; Saint Petersburg State University, 79 Universitetskaya Naberezhnaya, Saint Petersburg, 199034, Russia.
Jazyk:	angličtina
Zdroj:	Sovremennye tekhnologii v meditsine [Sovrem Tekhnologii Med] 2021; Vol. 12 (3), pp. 26-30. Date of Electronic Publication: 2020 Jun 28.
DOI:	10.17691/stm2020.12.3.03
Abstrakt:	The aim of the study was to identify the organized ventricular fibrillation (VF) activity in the dog heart and characterize its quantitative parameters during prolonged heart perfusion. Materials and Methods: A total of four experiments on isolated dog's hearts perfused with the blood of a supporting dog were performed. Episodes of VF were recorded in the form of an electrogram followed by a spectral analysis by the fast Fourier transform in the range of 0.5-15 Hz. The frequency, spectral power (amplitude), and relative weight (%) of the 1 st , 2 nd , and 3 rd highest amplitude oscillations were determined (frequency - mode; amplitude, relative weight - M±SEM; n=120). Results: In the perfused dog heart, VF was characterized by an organized activity, as evidenced by the dominant structure of the oscillation frequencies. Oscillations with a frequency of 9-10 Hz (occurring in 1/10 of the 0.5-15 Hz range) represent 42-44% of the spectral power and dominate the structure of the oscillation frequencies. The frequency and spectral power of the dominating oscillations proved to be stable thus indicating that under perfusion, VF did not cause disturbances in the heart organized activity. Conclusion: Our experimentation with isolated perfused hearts revealed the patterns of VF that could not be revealed in situ under conditions complicated by nerve factors and ischemia in VF. The results of the work are protected with a patent which is applicable for VF diagnosis in implantable defibrillators.
Databáze:	MEDLINE
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