Cognitive impairment and World Trade Centre-related exposures.

Autor: Clouston SAP; Program in Public Health, Department of Family, Population, and Preventive Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, USA. sean.clouston@stonybrookmedicine.edu., Hall CB; Saul R. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA.; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA., Kritikos M; Program in Public Health, Department of Family, Population, and Preventive Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, USA., Bennett DA; Rush Alzheimer's Disease Center, Department of Neurological Sciences, Rush Medical College, Rush University, Chicago, IL, USA., DeKosky S; Evelyn F. and William L. McKnight Brain Institute and Florida Alzheimer's Disease Research Center, Department of Neurology and Neuroscience, University of Florida, Gainesville, FL, USA., Edwards J; Department of Psychiatry and Behavioral Neuroscience, Morsani College of Medicine, University of South Florida, Tampa, FL, USA., Finch C; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA., Kreisl WC; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA., Mielke M; Specialized Center of Research Excellence on Sex Differences, Department of Neurology, Department of Epidemiology, Mayo Clinic, Rochester, MN, USA., Peskind ER; Veteran's Association VISN 20 Northwest Mental Illness Research, Education, and Clinical Center, Veteran's Affairs Puget Sound Health Care System, Seattle, WA, USA.; Alzheimer's Disease Research Center, Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA., Raskind M; Veteran's Association VISN 20 Northwest Mental Illness Research, Education, and Clinical Center, Veteran's Affairs Puget Sound Health Care System, Seattle, WA, USA.; Alzheimer's Disease Research Center, Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA., Richards M; Medical Research Council Unit for Lifelong Health and Ageing, Population Health Sciences, University College London, London, UK., Sloan RP; Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA., Spiro A 3rd; Department of Epidemiology, School of Public Health, Boston University, Boston, MA, USA.; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), Department of Veterans Affairs Boston Healthcare System, Boston, MA, USA., Vasdev N; Azrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Center, Center for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, ON, Canada., Brackbill R; World Trade Center Health Registry, New York Department of Health and Mental Hygiene, New York, NY, USA., Farfel M; World Trade Center Health Registry, New York Department of Health and Mental Hygiene, New York, NY, USA., Horton M; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Lowe S; The World Trade Center Mental Health Program, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Lucchini RG; Department of Environmental Health Sciences, Robert Stempel College of Public Health and Social Work, Florida International University, Miami, FL, USA., Prezant D; World Trade Center Health Program, Fire Department of the City of New York, Brooklyn, NY, USA.; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA., Reibman J; Department of Environmental Medicine, New York University Langone Health, New York, NY, USA., Rosen R; World Trade Center Environmental Health Center, Department of Psychiatry, New York University, New York, NY, USA., Seil K; World Trade Center Health Registry, New York Department of Health and Mental Hygiene, New York, NY, USA., Zeig-Owens R; World Trade Center Health Program, Fire Department of the City of New York, Brooklyn, NY, USA.; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA., Deri Y; Department of Medicine, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA.; Department of Psychiatry, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA., Diminich ED; Program in Public Health, Department of Family, Population, and Preventive Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, USA., Fausto BA; Center for Molecular & Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, NJ, USA., Gandy S; Research and Development Service, James J. Peters Department of Veterans Affairs Medical Center, Bronx, NY, USA.; Mount Sinai Alzheimer's Disease Research Center and Ronald M. Loeb Center for Alzheimer's Disease, Department of Psychiatry, Icahn School of Medicine, Mount Sinai, New York, NY, USA., Sano M; Research and Development Service, James J. Peters Department of Veterans Affairs Medical Center, Bronx, NY, USA.; Mount Sinai Alzheimer's Disease Research Center and Ronald M. Loeb Center for Alzheimer's Disease, Department of Psychiatry, Icahn School of Medicine, Mount Sinai, New York, NY, USA., Bromet EJ; Department of Psychiatry, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA., Luft BJ; Department of Medicine, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA.
Jazyk: angličtina
Zdroj: Nature reviews. Neurology [Nat Rev Neurol] 2022 Feb; Vol. 18 (2), pp. 103-116. Date of Electronic Publication: 2021 Nov 18.
DOI: 10.1038/s41582-021-00576-8
Abstrakt: On 11 September 2001 the World Trade Center (WTC) in New York was attacked by terrorists, causing the collapse of multiple buildings including the iconic 110-story 'Twin Towers'. Thousands of people died that day from the collapse of the buildings, fires, falling from the buildings, falling debris, or other related accidents. Survivors of the attacks, those who worked in search and rescue during and after the buildings collapsed, and those working in recovery and clean-up operations were exposed to severe psychological stressors. Concurrently, these 'WTC-affected' individuals breathed and ingested a mixture of organic and particulate neurotoxins and pro-inflammogens generated as a result of the attack and building collapse. Twenty years later, researchers have documented neurocognitive and motor dysfunctions that resemble the typical features of neurodegenerative disease in some WTC responders at midlife. Cortical atrophy, which usually manifests later in life, has also been observed in this population. Evidence indicates that neurocognitive symptoms and corresponding brain atrophy are associated with both physical exposures at the WTC and chronic post-traumatic stress disorder, including regularly re-experiencing traumatic memories of the events while awake or during sleep. Despite these findings, little is understood about the long-term effects of these physical and mental exposures on the brain health of WTC-affected individuals, and the potential for neurocognitive disorders. Here, we review the existing evidence concerning neurological outcomes in WTC-affected individuals, with the aim of contextualizing this research for policymakers, researchers and clinicians and educating WTC-affected individuals and their friends and families. We conclude by providing a rationale and recommendations for monitoring the neurological health of WTC-affected individuals.
(© 2021. Springer Nature Limited.)
Databáze: MEDLINE
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