Characterizing the postnatal hypothalamic-pituitary-adrenal axis response of in utero heat stressed pigs at 10 and 15 weeks of age.

Autor: Maskal JM; Department of Animal Sciences, Purdue University, West Lafayette, IN, 47907, USA., Brito LF; Department of Animal Sciences, Purdue University, West Lafayette, IN, 47907, USA., Duttlinger AW; Department of Animal Sciences, Purdue University, West Lafayette, IN, 47907, USA., Kpodo KR; Department of Animal Sciences, Purdue University, West Lafayette, IN, 47907, USA., McConn BR; Oak Ridge Institute for Science and Education, Oak Ridge, TN, 37830, USA., Byrd CJ; Department of Animal Sciences, Purdue University, West Lafayette, IN, 47907, USA., Richert BT; Department of Animal Sciences, Purdue University, West Lafayette, IN, 47907, USA., Marchant JN; Livestock Behavior Research Unit, USDA-ARS, West Lafayette, IN, 47907, USA., Lay DC Jr; Livestock Behavior Research Unit, USDA-ARS, West Lafayette, IN, 47907, USA., Perry SD; Division of Animal Sciences, University of Missouri, Columbia, MO, 65221, USA., Lucy MC; Division of Animal Sciences, University of Missouri, Columbia, MO, 65221, USA., Safranski TJ; Division of Animal Sciences, University of Missouri, Columbia, MO, 65221, USA., Johnson JS; Livestock Behavior Research Unit, USDA-ARS, West Lafayette, IN, 47907, USA. Jay.Johnson2@usda.gov.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2021 Nov 18; Vol. 11 (1), pp. 22527. Date of Electronic Publication: 2021 Nov 18.
DOI: 10.1038/s41598-021-01889-w
Abstrakt: In utero heat stress alters postnatal physiological and behavioral stress responses in pigs. However, the mechanisms underlying these alterations have not been determined. The study objective was to characterize the postnatal hypothalamic-pituitary-adrenal axis response of in utero heat-stressed pigs. Pigs were subjected to a dexamethasone suppression test followed by a corticotrophin releasing hormone challenge at 10 and 15 weeks of age. Following the challenge, hypothalamic, pituitary, and adrenal tissues were collected from all pigs for mRNA abundance analyses. At 10 weeks of age, in utero heat-stressed pigs had a reduced (P < 0.05) cortisol response to the corticotrophin releasing hormone challenge versus controls. Additionally, the cortisol response tended to be greater overall (P < 0.10) in 15 versus 10-week-old pigs in response to the dexamethasone suppression test. The cortisol response tended to be reduced overall (P < 0.10) in 15 versus 10-week-old pigs in response to the corticotrophin releasing hormone challenge. Hypothalamic corticotropin releasing hormone mRNA abundance tended to be greater (P < 0.10) in in utero heat-stressed versus control pigs at 15-weeks of age. In summary, in utero heat stress altered some aspects of the hypothalamic-pituitary-adrenal axis related to corticotropin releasing hormone signaling, and age influenced this response.
(© 2021. The Author(s).)
Databáze: MEDLINE
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