Central nervous system ALK-negative anaplastic large cell lymphoma with IRF4/DUSP22 rearrangement.

Autor: Magaki S; Section of Neuropathology, Department of Pathology and Laboratory Medicine, UCLA Medical Center and David Geffen School of Medicine, Los Angeles, CA, USA. smagaki@mednet.ucla.edu., Satyadev R; Department of Pathology, Kaiser Foundation Hospital, Anaheim, CA, USA., Chen Z; Section of Neuropathology, Department of Pathology and Laboratory Medicine, UCLA Medical Center and David Geffen School of Medicine, Los Angeles, CA, USA.; Centre Hospitalier Universitaire Sainte-Justine, Montréal, QC, Canada., Yung KS; Department of Radiology, Kaiser Permanente Irvine Medical Center, Irvine, CA, USA., Vinters HV; Section of Neuropathology, Department of Pathology and Laboratory Medicine, UCLA Medical Center and David Geffen School of Medicine, Los Angeles, CA, USA.; Department of Neurology, UCLA Medical Center and David Geffen School of Medicine, Los Angeles, CA, USA.; Brain Research Institute, UCLA Medical Center and David Geffen School of Medicine, Los Angeles, CA, USA., Kinney MC; Division of Hematopathology, Department of Pathology and Laboratory Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Said JW; Department of Pathology and Laboratory Medicine, UCLA Medical Center and David Geffen School of Medicine, Los Angeles, USA.
Jazyk: angličtina
Zdroj: Brain tumor pathology [Brain Tumor Pathol] 2022 Jan; Vol. 39 (1), pp. 25-34. Date of Electronic Publication: 2021 Nov 18.
DOI: 10.1007/s10014-021-00415-0
Abstrakt: Anaplastic large cell lymphomas (ALCL) are mature T-cell neoplasms, approximately half of which harbor rearrangements of the ALK gene that confer a good prognosis. Recent studies have demonstrated that a significant proportion of ALK-negative ALCLs demonstrate rearrangements of the IRF4/DUSP22 locus that also are typically associated with a favorable prognosis. ALCL with primary involvement of the central nervous system (CNS) is extremely rare. We report what may be the first case of ALK-negative ALCL with IRF4/DUSP22 rearrangement involving the brain in a 55-year-old man. Magnetic resonance imaging demonstrated signal abnormalities in the periventricular region, corpus callosum and cingulate gyrus. Biopsy revealed a diffuse parenchymal and angiocentric infiltrate of CD30-positive cells that showed IRF4/DUSP22 rearrangement by fluorescence in situ hybridization. We also review the clinical and pathologic features of primary CNS ALK-negative ALCLs in the literature and highlight the need for awareness of this entity to optimize appropriate management.
(© 2021. The Author(s).)
Databáze: MEDLINE
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