Diagnostic concordance of pathological methods and reports of hematopathologists compared to local nonspecialized pathologists in the diagnosis of lymphoma in Mexico.

Autor: Solano Genesta M; Hematology Service, Instituto Oncologico Nacional, Guadalajara, México., Garcia Gonzalez LA; Hematology Service, Instituto Oncologico Nacional, Guadalajara, México., Rubio Macias FJ; Hematology Service, Instituto Oncologico Nacional, Guadalajara, México., Rojas LV; Hematology Service, Instituto Oncologico Nacional, Guadalajara, México., Luna Gonzalez CA; Hematology Service, Instituto Oncologico Nacional, Guadalajara, México., Ramirez OJP; Hematology Service, Hospital Central Dr. Ignácio Morones Prieto, San Luís Potosí, México., Ceballos Lopez AA; Hematology Service, Clínica de Mérida, Mérida, México., Garcia AC; Hematology Service, Hospital Regional de Alta Especialidad de Ixtapaluca, Ixtapaluca, México., Ortiz LA; Hematology Service, Hospital H, Los Cabos, San José del Cabo, México., Hernandez RM; Hematology Service, Clínica del Valle, Ciudad Victoria, México., Gomez-Almaguer D; Hematology Service, Hospital Universitario 'Dr. José E. González' Universidad Autónoma de Nuevo León, Nuevo León, México., Maldonado MDCL; Department of Immunopathology, National Cancer Institute, Mexico City, México., Bernal PYLA; Department of Pathology, Doctor's Hospital, Monterrey, México., Osorno AZ; Department of Hematopathology, Hospital Español, Mexico City, México., Ramos JR; Medical Affairs, Janssen Inc, Buenos Aires, Argentina., Barreyro P; Medical Affairs, Janssen Inc, Buenos Aires, Argentina., Herrera Rojas MA; Medical Affairs, Janssen Inc, Buenos Aires, Argentina.
Jazyk: angličtina
Zdroj: Hematology (Amsterdam, Netherlands) [Hematology] 2021 Dec; Vol. 26 (1), pp. 940-944.
DOI: 10.1080/16078454.2021.1997414
Abstrakt: Objectives: To assess the concordance between lymphoma diagnoses made via tissue biopsy by local pathologists and also to assess the after review of these specimens by more specialized hematopathologists.
Methods: A prospective, non-interventional and multicenter study was conducted at seven sites in Mexico from January 2017 to October 2017. Eligible biopsies were sampled from patients with a previous diagnosis of lymphoma on lymph node biopsy or a diagnosis of extranodal lymphoma, with adequate amount and tissue preservation for the review analysis. The biopsy tissues reviewed by local pathologists were also reviewed by hematopathologists participating in the study. The concordance in diagnosis results was classified into three categories: diagnostic agreement, minor discrepancy and major discrepancy.
Results: Out of 111 samples received, 105 samples met the eligibility criteria and were included for full analysis. The median patient age (range) was 54 (16-94) years. A diagnostic agreement was observed in 23 (21.9%) biopsies, minor discrepancies were observed in 32 (30.5%) biopsies and major discrepancies were observed in 50 (47.6%) biopsies. Diagnostic concordance varied across the seven study sites; the rate of major discrepancies ranged from 0% to 100% and the rate of diagnostic agreement ranged from 0% to 81.8%. Out of the 105 reviewed biopsies, a total of 89 cases were diagnosed as lymphoma by hematopathologists.
Conclusions: This study showed that major discrepancies were observed following the review by hematopathologists compared with that of the local pathologist's initial diagnosis in nearly one-half cases. In addition, there was a wide variation in the percentage of diagnostic agreements and discrepancies among different study sites.
Databáze: MEDLINE
Externí odkaz: