Hydrogen Sulfide: An Emerging Precision Strategy for Gas Therapy.

Autor: Ding H; Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Materials Science and Chemical Engineering, Harbin Engineering University, Harbin, 150001, P. R. China., Chang J; Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Materials Science and Chemical Engineering, Harbin Engineering University, Harbin, 150001, P. R. China., He F; Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Materials Science and Chemical Engineering, Harbin Engineering University, Harbin, 150001, P. R. China., Gai S; Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Materials Science and Chemical Engineering, Harbin Engineering University, Harbin, 150001, P. R. China., Yang P; Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Materials Science and Chemical Engineering, Harbin Engineering University, Harbin, 150001, P. R. China.
Jazyk: angličtina
Zdroj: Advanced healthcare materials [Adv Healthc Mater] 2022 Feb; Vol. 11 (4), pp. e2101984. Date of Electronic Publication: 2021 Nov 27.
DOI: 10.1002/adhm.202101984
Abstrakt: Advances in nanotechnology have enabled the rapid development of stimuli-responsive therapeutic nanomaterials for precision gas therapy. Hydrogen sulfide (H 2 S) is a significant gaseous signaling molecule with intrinsic biochemical properties, which exerts its various physiological effects under both normal and pathological conditions. Various nanomaterials with H 2 S-responsive properties, as new-generation therapeutic agents, are explored to guide therapeutic behaviors in biological milieu. The cross disciplinary of H 2 S is an emerging scientific hotspot that studies the chemical properties, biological mechanisms, and therapeutic effects of H 2 S. This review summarizes the state-of-art research on H 2 S-related nanomedicines. In particular, recent advances in H 2 S therapeutics for cancer, such as H 2 S-mediated gas therapy and H 2 S-related synergistic therapies (combined with chemotherapy, photodynamic therapy, photothermal therapy, and chemodynamic therapy) are highlighted. Versatile imaging techniques for real-time monitoring H 2 S during biological diagnosis are reviewed. Finally, the biosafety issues, current challenges, and potential possibilities in the evolution of H 2 S-based therapy that facilitate clinical translation to patients are discussed.
(© 2021 Wiley-VCH GmbH.)
Databáze: MEDLINE
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