Group B Streptococcus Capsular Serotype Alters Vaginal Colonization Fitness.

Autor:	Dammann AN; Department of Pediatrics, New York University Grossman School of Medicine, New York, New York, USA., Chamby AB; Department of Pediatrics, New York University Grossman School of Medicine, New York, New York, USA., Gonzalez FJ; Department of Pediatrics, New York University Grossman School of Medicine, New York, New York, USA., Sharp ME; Department of Microbiology, New York University Grossman School of Medicine, New York, New York, USA., Flores K; Department of Microbiology, New York University Grossman School of Medicine, New York, New York, USA., Shahi I; Department of Microbiology, New York University Grossman School of Medicine, New York, New York, USA., Dongas S; Department of Pediatrics, New York University Grossman School of Medicine, New York, New York, USA., Hooven TA; Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.; Richard King Mellon Institute for Pediatric Research, University of Pittsburgh Medical Center, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA., Ratner AJ; Department of Pediatrics, New York University Grossman School of Medicine, New York, New York, USA.; Department of Microbiology, New York University Grossman School of Medicine, New York, New York, USA.
Jazyk:	angličtina
Zdroj:	The Journal of infectious diseases [J Infect Dis] 2022 Jun 01; Vol. 225 (11), pp. 1896-1904.
DOI:	10.1093/infdis/jiab559
Abstrakt:	Background: Group B Streptococcus (GBS) remains a leading cause of infant morbidity and mortality. A candidate vaccine targets 6 GBS serotypes, offering a potential alternative to intrapartum antibiotic prophylaxis to reduce disease burden. However, our understanding of the contributions of specific capsule types to GBS colonization and disease remains limited. Methods: Using allelic exchange, we generated isogenic GBS strains differing only in the serotype-determining region in 2 genetic backgrounds, including the hypervirulent clonal complex (CC) 17. Using a murine model of vaginal cocolonization, we evaluated the roles of the presence of capsule and of expression of specific capsular types in GBS vaginal colonization fitness independent of other genetic factors. Results: Encapsulated wild-type strains COH1 (CC17, serotype III) and A909 (non-CC17, serotype Ia) outcompeted isogenic acapsular mutants in murine vaginal cocolonization. COH1 wild type outcompeted A909. Notably, expression of type Ia capsule conferred an advantage over type III capsule in both genetic backgrounds. Conclusions: Specific capsule types may provide an advantage in GBS vaginal colonization in vivo. However, success of certain GBS lineages, including CC17, likely involves both capsule and noncapsule genetic elements. Capsule switching in GBS, a potential outcome of conjugate vaccine programs, may alter colonization fitness or pathogenesis. (© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu