Building up DNA, bit by bit: a simple description of chain assembly.
| Autor: | Foffi R; Dipartimento di Fisica, Sapienza Università di Roma, Piazzale Moro 5, I-00185 Rome, Italy. francesco.sciortino@uniroma1.it., Sciortino F; Dipartimento di Fisica, Sapienza Università di Roma, Piazzale Moro 5, I-00185 Rome, Italy. francesco.sciortino@uniroma1.it., Tavares JM; ISEL - Instituto Superior de Engenharia de Lisboa, Instituto Politécnico de Lisboa, Rua Conselheiro Emídio Navarro 1, 1959-007 Lisboa, Portugal. jose.tavares@isel.pt.; Centro de Física Teórica e Computacional, Faculdade de Ciências da Universidade de Lisboa, P-1749-016 Lisboa, Portugal. piteixeira@fc.ul.pt., Teixeira PIC; ISEL - Instituto Superior de Engenharia de Lisboa, Instituto Politécnico de Lisboa, Rua Conselheiro Emídio Navarro 1, 1959-007 Lisboa, Portugal. jose.tavares@isel.pt.; Centro de Física Teórica e Computacional, Faculdade de Ciências da Universidade de Lisboa, P-1749-016 Lisboa, Portugal. piteixeira@fc.ul.pt. |
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| Jazyk: | angličtina |
| Zdroj: | Soft matter [Soft Matter] 2021 Dec 08; Vol. 17 (47), pp. 10736-10743. Date of Electronic Publication: 2021 Dec 08. |
| DOI: | 10.1039/d1sm01130h |
| Abstrakt: | We simulate the assembly of DNA copolymers from two types of short duplexes (short double strands with a single-stranded overhang at each end), as described by the oxDNA model. We find that the statistics of chain lengths can be well reproduced by a simple theory that treats the association of particles into ideal ( i.e. , non-interacting) clusters as a reversible chemical reaction. The reaction constants can be predicted either from SantaLucia's theory or from Wertheim's thermodynamic perturbation theory of association for spherical patchy particles. Our results suggest that theories incorporating very limited molecular detail may be useful for predicting the broad equilibrium features of copolymerisation. |
| Databáze: | MEDLINE |
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