The underlying mechanisms for severe COVID-19 progression in people with diabetes mellitus: a critical review.

Autor: Figueroa-Pizano MD; Research Center for Food and Development, CIAD, AC, Carretera Gustavo Enrique Astiazarán Rosas No. 46, C.P. 83304, Hermosillo, Sonora, México., Campa-Mada AC; Research Center for Food and Development, CIAD, AC, Carretera Gustavo Enrique Astiazarán Rosas No. 46, C.P. 83304, Hermosillo, Sonora, México., Carvajal-Millan E; Research Center for Food and Development, CIAD, AC, Carretera Gustavo Enrique Astiazarán Rosas No. 46, C.P. 83304, Hermosillo, Sonora, México., Martinez-Robinson KG; Research Center for Food and Development, CIAD, AC, Carretera Gustavo Enrique Astiazarán Rosas No. 46, C.P. 83304, Hermosillo, Sonora, México., Chu AR; Research Center for Food and Development, CIAD, AC, Carretera Gustavo Enrique Astiazarán Rosas No. 46, C.P. 83304, Hermosillo, Sonora, México.
Jazyk: angličtina
Zdroj: AIMS public health [AIMS Public Health] 2021 Oct 26; Vol. 8 (4), pp. 720-742. Date of Electronic Publication: 2021 Oct 26 (Print Publication: 2021).
DOI: 10.3934/publichealth.2021057
Abstrakt: Diabetes mellitus (DM) has a high incidence of comorbidities among patients with severe coronavirus disease 2019 (COVID-19). The elevated prevalence of DM in the world population makes it a significant risk factor because diabetic individuals appear to be prone to clinical complications and have increased mortality rates. Here, we review the possible underlying mechanisms involved in DM that led to worse outcomes in COVID-19. The impacts of hyperglycemia side effects, secondary comorbidities, weakened innate and adaptive immunity, chronic inflammation, and poor nutritional status, commonly present in DM, are discussed. The role of the SARS-CoV-2 receptor and its polymorphic variations on higher binding affinity to facilitate viral uptake in people with DM were also considered. Clinical differences between individuals with type 1 DM and type 2 DM affected by COVID-19 and the potential diabetogenic effect of SARS-CoV-2 infection were addressed.
Competing Interests: Conflict of interest: All authors declare no conflicts of interest in this paper.
(© 2021 the Author(s), licensee AIMS Press.)
Databáze: MEDLINE
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