Enhanced osseointegration through direct energy deposition porous coating for cementless orthopedic implant fixation.

Autor: Ryu DJ; Department of Orthopedic Surgery, Inha University Hospital, 27 Inhang-Ro, Jung-Gu, Incheon, 22332, South Korea.; Department of Orthopedic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-Ro, Gangnam-Gu, Seoul, 06351, South Korea., Jung A; Department of Mechanical Engineering, Sejong University, 209 Neungdong-ro, Gwangjin-Gu, Seoul, 05006, South Korea., Ban HY; Department of Mechanical Engineering, Sejong University, 209 Neungdong-ro, Gwangjin-Gu, Seoul, 05006, South Korea., Kwak TY; Department of Mechanical Engineering, Sejong University, 209 Neungdong-ro, Gwangjin-Gu, Seoul, 05006, South Korea., Shin EJ; Samsung Biomedical Research Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, 06351, South Korea., Gweon B; Department of Mechanical Engineering, Sejong University, 209 Neungdong-ro, Gwangjin-Gu, Seoul, 05006, South Korea. bgweon@seong.ac.kr., Lim D; Department of Mechanical Engineering, Sejong University, 209 Neungdong-ro, Gwangjin-Gu, Seoul, 05006, South Korea. dli349@sejong.ac.kr., Wang JH; Department of Orthopedic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-Ro, Gangnam-Gu, Seoul, 06351, South Korea. mdwang88@gmail.com.; Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, 06351, South Korea. mdwang88@gmail.com.; Department of Medical Device Management and Research, SAIHST, Sungkyunkwan University, Seoul, 06351, South Korea. mdwang88@gmail.com.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2021 Nov 16; Vol. 11 (1), pp. 22317. Date of Electronic Publication: 2021 Nov 16.
DOI: 10.1038/s41598-021-01739-9
Abstrakt: Direct energy deposition (DED) is a newly developed 3D metal printing technique that can be utilized on a porous surface coating of joint implants, however there is still a lack of studies on what advantages DED has over conventional techniques. We conducted a systematic mechanical and biological comparative study of porous coatings prepared using the DED method and other commercially available technologies including titanium plasma spray (TPS), and powder bed fusion (PBF). DED showed higher porosity surface (48.54%) than TPS (21.4%) and PBF (35.91%) with comparable fatigue cycle. At initial cell adhesion, cells on DED and PBF surface appeared to spread well with distinct actin stress fibers through immunofluorescence study. It means that the osteoblasts bind more strongly to the DED and PBF surface. Also, DED surface showed higher cell proliferation (1.27 times higher than TPS and PBF) and osteoblast cell activity (1.28 times higher than PBF) for 2 weeks culture in vitro test. In addition, DED surface showed better bone to implant contact and new bone formation than TPS in in vivo study. DED surface also showed consistently good osseointegration performance throughout the early and late period of osseointegration. Collectively, these results show that the DED coating method is an innovative technology that can be utilized to make cementless joint implants.
(© 2021. The Author(s).)
Databáze: MEDLINE
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