Binder jetting 3D printing of challenging medicines: From low dose tablets to hydrophobic molecules.

Autor: Kozakiewicz-Latała M; Department of Drug Forms Technology, Wroclaw Medical University, Borowska 211 A, 50-556 Wroclaw, Poland., Nartowski KP; Department of Drug Forms Technology, Wroclaw Medical University, Borowska 211 A, 50-556 Wroclaw, Poland. Electronic address: karol.nartowski@umed.wroc.pl., Dominik A; Department of Drug Forms Technology, Wroclaw Medical University, Borowska 211 A, 50-556 Wroclaw, Poland., Malec K; Department of Drug Forms Technology, Wroclaw Medical University, Borowska 211 A, 50-556 Wroclaw, Poland., Gołkowska AM; Department of Drug Forms Technology, Wroclaw Medical University, Borowska 211 A, 50-556 Wroclaw, Poland., Złocińska A; Laboratory of Elemental Analysis and Structural Research, Wroclaw Medical University, Borowska 211 A, 50-556 Wroclaw, Poland., Rusińska M; Centre for Advanced Manufacturing Technologies (CAMT/FPC), Wroclaw University of Science and Technology, Lukasiewicza 5, 50-371 Wroclaw, Poland., Szymczyk-Ziółkowska P; Centre for Advanced Manufacturing Technologies (CAMT/FPC), Wroclaw University of Science and Technology, Lukasiewicza 5, 50-371 Wroclaw, Poland., Ziółkowski G; Centre for Advanced Manufacturing Technologies (CAMT/FPC), Wroclaw University of Science and Technology, Lukasiewicza 5, 50-371 Wroclaw, Poland., Górniak A; Laboratory of Elemental Analysis and Structural Research, Wroclaw Medical University, Borowska 211 A, 50-556 Wroclaw, Poland., Karolewicz B; Department of Drug Forms Technology, Wroclaw Medical University, Borowska 211 A, 50-556 Wroclaw, Poland.
Jazyk: angličtina
Zdroj: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V [Eur J Pharm Biopharm] 2022 Jan; Vol. 170, pp. 144-159. Date of Electronic Publication: 2021 Nov 13.
DOI: 10.1016/j.ejpb.2021.11.001
Abstrakt: Increasing access to additive manufacturing technologies utilising easily available desktop devices opened novel ways for formulation of personalized medicines. It is, however, challenging to propose a flexible and robust formulation platform which can be used for fabrication of tailored solid dosage forms composed of APIs with different properties (e.g., hydrophobicity) without extensive optimization. This manuscript presents a strategy for formulation of fast dissolving tablets using binder jetting (BJ) technology. The approach is demonstrated using two model APIs: hydrophilic quinapril hydrochloride (QHCl, logP = 1.4) and hydrophobic clotrimazole (CLO, logP = 5.4). The proposed printing method uses inexpensive, well known, and easily available FDA approved pharmaceutical excipients. The obtained model tablets had uniform content of the drug, excellent mechanical properties, and highly porous structure resulting in short disintegration time and fast dissolution rate. The tablets could be scaled and obtained in predesigned shapes and sizes. The proposed method may find its application in the early stages of drug development where high flexibility of the formulation is required and the amount of available API is limited.
(Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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