Assessment of Serum Bactericidal and Opsonophagocytic Activity of Antibodies to Gonococcal Vaccine Targets.

Autor:	Semchenko EA; Institute for Glycomics, Griffith University, Gold Coast, QLD, Australia. e.semchenko@griffith.edu.au., Jen FE; Institute for Glycomics, Griffith University, Gold Coast, QLD, Australia., Jennings MP; Institute for Glycomics, Griffith University, Gold Coast, QLD, Australia., Seib KL; Institute for Glycomics, Griffith University, Gold Coast, QLD, Australia. k.seib@griffith.edu.au.
Jazyk:	angličtina
Zdroj:	Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2022; Vol. 2414, pp. 363-372.
DOI:	10.1007/978-1-0716-1900-1_19
Abstrakt:	There is no vaccine available to prevent Neisseria gonorrhoeae infection, however there is currently a high level of interest in developing gonococcal vaccines due to the increasing number of cases and continuing emergence of antimicrobial resistance worldwide. A key aspect of vaccine development is the investigation of the functional immune response raised to the vaccine targets under investigation. Here, we describe two assays used to assess the functional immune response raised against gonococcal vaccine targets: the serum bactericidal assay (SBA) and the opsonophagocytic assay (OPA). (© 2022. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze:	MEDLINE
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