Prevalence and risk factor analysis for HIV/HTLV 1/2 coinfection in Paraíba state, Brazil.

Autor: Santos de Souza M; Virology Sector, Keizo Asami Immunopathology Laboratory, Federal University of Pernambuco, Recife, Pernambuco, Brazil., Prado Gonçales J; Virology Sector, Keizo Asami Immunopathology Laboratory, Federal University of Pernambuco, Recife, Pernambuco, Brazil., Santos deMorais VM; Virology Sector, Keizo Asami Immunopathology Laboratory, Federal University of Pernambuco, Recife, Pernambuco, Brazil., Silva Júnior JVJ; Virology Sector, Keizo Asami Immunopathology Laboratory, Federal University of Pernambuco, Recife, Pernambuco, Brazil., Lopes TRR; Virology Sector, Keizo Asami Immunopathology Laboratory, Federal University of Pernambuco, Recife, Pernambuco, Brazil., Costa JEFD; Virology Sector, Keizo Asami Immunopathology Laboratory, Federal University of Pernambuco, Recife, Pernambuco, Brazil., Côelho MRCD; Virology Sector, Keizo Asami Immunopathology Laboratory, Federal University of Pernambuco, Recife, Pernambuco, Brazil. rcoelholika@gmail.com.
Jazyk: angličtina
Zdroj: Journal of infection in developing countries [J Infect Dev Ctries] 2021 Oct 31; Vol. 15 (10), pp. 1551-1554. Date of Electronic Publication: 2021 Oct 31.
DOI: 10.3855/jidc.14602
Abstrakt: Introduction: Human T-lymphotropic virus (HTLV) 1 and 2 infections can lead to neurological diseases, mainly in HIV/HTLV 1 coinfected. Furthermore, HTLV 1 infection in HIV/AIDS patients has also been associated with AIDS progression. Despite this, HTLV 1/2 infections are not of mandatory notification in Brazil. Here, we describe the prevalence of HTLV 1/2 in HIV/AIDS patients from Paraíba state, Brazil, as well as the sociodemographic characteristics of the coinfected individuals.
Methodology: Information about HIV viral load and TCD4 lymphocyte count were obtained from patients' records. Data on the patients' sociodemographic characteristics were obtained by interview conducted after signing the informed consent form. The serological diagnosis for HTLV 1/2 was performed by Enzyme-Linked Immunosorbent Assay (ELISA) and Western Blot (WB).
Results: A total of 401 HIV/AIDS patients participated in the study, of whom about 1.5% (6/401) were positive for antibodies against HTLV, specifically for HTLV 1, evaluated by both ELISA and WB. No risk factors were found associated with HIV/HTLV 1/2 coinfection.
Conclusions: We report a 1.5% prevalence of HTLV 1 infection in HIV/AIDS patients from Paraíba state. Although we have not identified risk factors associated with HTLV 1, we describe the most observed sociodemographic characteristics in HIV/HTLV 1 coinfection.
Competing Interests: No Conflict of Interest is declared
(Copyright (c) 2021 Marcela Santos de Souza, Juliana Prado Goncales, Viviane Martha Santos deMorais, Jose Valter Joaquim Silva Junior, Thaisa Regina Rocha Lopes, Joanne Elizabeth Ferraz da Costa, Maria Rosangela Cunha Duarte Coelho.)
Databáze: MEDLINE
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