Altered Dynamic Brain Connectivity in Individuals With Sickle Cell Disease and Chronic Pain Secondary to Hip Osteonecrosis.

Autor:	Santana JERS; Health and Functionality Study Group, 28111Federal University of Bahia, Salvador, Brazil.; Postgraduate Program in Medicine and Health, 28111Federal University of Bahia, Salvador, Brazil., Baptista AF; Health and Functionality Study Group, 28111Federal University of Bahia, Salvador, Brazil.; Postgraduate Program in Medicine and Health, 28111Federal University of Bahia, Salvador, Brazil.; Center for Mathematics, Computation and Cognition, 488583Federal University of ABC, Santo Andre, Brazil., Lucena R; Health and Functionality Study Group, 28111Federal University of Bahia, Salvador, Brazil.; Postgraduate Program in Medicine and Health, 28111Federal University of Bahia, Salvador, Brazil.; Medical School of Bahia, 28111Federal University of Bahia, Salvador, Brazil., Lopes TDS; Health and Functionality Study Group, 28111Federal University of Bahia, Salvador, Brazil.; Postgraduate Program in Medicine and Health, 28111Federal University of Bahia, Salvador, Brazil.; Adventist Neuromodulation and Neuroscience Laboratory, Bahia Adventist College, Cachoeira, Brazil., do Rosário RS; Health and Functionality Study Group, 28111Federal University of Bahia, Salvador, Brazil.; Institute of Physics, Federal University of Bahia, Salvador, Brazil., Xavier MR; Health and Functionality Study Group, 28111Federal University of Bahia, Salvador, Brazil., Fonseca A; Center for Mathematics, Computation and Cognition, 488583Federal University of ABC, Santo Andre, Brazil., Miranda JGV; Health and Functionality Study Group, 28111Federal University of Bahia, Salvador, Brazil.; Institute of Physics, Federal University of Bahia, Salvador, Brazil.
Jazyk:	angličtina
Zdroj:	Clinical EEG and neuroscience [Clin EEG Neurosci] 2023 May; Vol. 54 (3), pp. 333-342. Date of Electronic Publication: 2021 Nov 13.
DOI:	10.1177/15500594211054297
Abstrakt:	Individuals with sickle cell disease (SCD) exhibit changes in static brain connectivity in rest. However, little known as chronic pain associated with hip osteonecrosis affects dynamic brain connectivity during rest and the motor imagery task. The aim of this study was to investigate the characteristics of the dynamic functional brain connectivity of individuals with SCD and chronic pain secondary to hip osteonecrosis. This is a cross-sectional study comparing the dynamic brain connectivity of healthy individuals (n = 18) with the dynamic brain connectivity of individuals with SCD and chronic pain (n = 22). Individuals with SCD and chronic pain were stratified into high- or low-intensity pain groups based on pain intensity at the time of assessment. Dynamic brain connectivity was assessed through electroencephalography in 3 stages, resting state with eyes closed, and during hip (painful for the SCD individuals) and hand (control, nonpainful) motor imagery. Average weight of the edges and full synchronization time (FST)-time required for 95% of the possible edges to appear over time during a given task-were evaluated. Regarding the average weight of the edges, individuals with SCD and high-intensity pain presented higher edge weight during hip motor imagery. The average weight of the edges correlated positively with pain intensity and depression symptoms. Individuals with SCD and chronic pain complete the cerebral network at rest more quickly (lower FST). Individuals with SCD and chronic pain/hip osteonecrosis have impaired dynamic brain network with shorter FST in rest network and more pronounced diffuse connectivity in individuals with high-intensity pain. The dynamic brain network evaluated by time-varying graphs and motif synchronization was able to identify differences between groups.
Databáze:	MEDLINE
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