Synthesis, Characterization, and Cellular Uptake of Magnesium Maltol and Ethylmaltol Complexes.

Autor:	Case DR; Department of Chemistry, Syracuse University, 111 College Place, Syracuse, New York 13244, United States., Gonzalez R; Balchem Corporation, 52 Sunrise Park Road, New Hampton, New York 10958, United States., Zubieta J; Department of Chemistry, Syracuse University, 111 College Place, Syracuse, New York 13244, United States., Doyle RP; Department of Chemistry, Syracuse University, 111 College Place, Syracuse, New York 13244, United States.
Jazyk:	angličtina
Zdroj:	ACS omega [ACS Omega] 2021 Oct 28; Vol. 6 (44), pp. 29713-29723. Date of Electronic Publication: 2021 Oct 28 (Print Publication: 2021).
DOI:	10.1021/acsomega.1c04104
Abstrakt:	Magnesium deficiency and/or deficit (hypomagnesemia, <0.75 mmol/L in the blood) has become a recognized problem in healthcare and clinical settings. Concomitantly, supplementation has become recognized as the primary means of mitigating such deficiencies. Common magnesium supplements typically suffer from shortcomings: rapid dissociation and subsequent laxation (magnesium salts: e.g., magnesium chloride), poor water solubility (magnesium oxides and hydroxides), poor characterizability (magnesium chelates), and are/or use of non-natural ligands. To this end, there is a need for the development of fully characterized, water-soluble, all-natural magnesium compounds. Herein, we discuss the synthesis, solution and solid-state characterization, aqueous solubility, and cellular uptake of magnesium complexes of maltol and ethylmaltol, ligands whose magnesium complexes have yet to be fully explored. Competing Interests: The authors declare the following competing financial interest(s): I sit on the scientific advisory board of Balchem, with whom this paper is a collaboration. No funding for this paper was received from Balchem for this work. (© 2021 The Authors. Published by American Chemical Society.)
Databáze:	MEDLINE
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