Persisting Motor Function Problems in School-Aged Survivors of Congenital Diaphragmatic Hernia.

Autor:	de Munck S; Department of Pediatric Surgery and Pediatric Intensive Care, Erasmus MC Sophia Children's Hospital, Rotterdam, Netherlands., van der Cammen-van Zijp MHM; Department of Pediatric Surgery and Pediatric Intensive Care, Erasmus MC Sophia Children's Hospital, Rotterdam, Netherlands., Zanen-van den Adel TPL; Department of Orthopedics, Section of Physical Therapy, Erasmus MC Sophia Children's Hospital, Rotterdam, Netherlands., Wijnen RMH; Department of Pediatric Surgery and Pediatric Intensive Care, Erasmus MC Sophia Children's Hospital, Rotterdam, Netherlands., Cochius-den Otter SCM; Department of Pediatric Surgery and Pediatric Intensive Care, Erasmus MC Sophia Children's Hospital, Rotterdam, Netherlands., van Haren NEM; Department of Child and Adolescent Psychiatry and Psychology, Erasmus MC Sophia Children's Hospital, Rotterdam, Netherlands., Gischler SJ; Department of Pediatric Surgery and Pediatric Intensive Care, Erasmus MC Sophia Children's Hospital, Rotterdam, Netherlands., van Rosmalen J; Department of Biostatistics, Erasmus MC, Rotterdam, Netherlands.; Department of Epidemiology, Erasmus MC, Rotterdam, Netherlands., IJsselstijn H; Department of Pediatric Surgery and Pediatric Intensive Care, Erasmus MC Sophia Children's Hospital, Rotterdam, Netherlands.
Jazyk:	angličtina
Zdroj:	Frontiers in pediatrics [Front Pediatr] 2021 Oct 27; Vol. 9, pp. 729054. Date of Electronic Publication: 2021 Oct 27 (Print Publication: 2021).
DOI:	10.3389/fped.2021.729054
Abstrakt:	Background and Objectives: Children born with congenital diaphragmatic hernia (CDH) and treated with extracorporeal membrane oxygenation (ECMO), are at risk for motor function impairment during childhood. We hypothesized that all children born with CDH are at risk for persistent motor function impairment, irrespective of ECMO-treatment. We longitudinally assessed these children's motor function. Methods: Children with CDH with and without ECMO-treatment, born 1999-2007, who joined our structural prospective follow-up program were assessed with the Movement Assessment Battery for Children (M-ABC) at 5, 8, 12 years. Z-scores were used in a general linear model for longitudinal analysis. Results: We included 55 children, of whom 25 had been treated with ECMO. Forty-three (78%) were evaluated at three ages. Estimated mean (95% CI) z-scores from the general linear model were -0.67 (-0.96 to -0.39) at 5 years of age, -0.35 (-0.65 to -0.05) at 8 years, and -0.46 (-0.76 to -0.17) at 12 years. The 5- and 8-years scores differed significantly ( p = 0.02). Motor development was significantly below the norm in non-ECMO treated patients at five years; -0.44 (-0.83 to -0.05), and at all ages in the ECMO-treated-patients: -0.90 (-1.32 to -0.49), -0.45 (-0.90 to -0.02) and -0.75 (-1.2 to -0.34) at 5, 8, and 12 years, respectively. Length of hospital stay was negatively associated with estimated total z-score M-ABC ( p = 0.004 multivariate analysis). Conclusion: School-age children born with CDH are at risk for motor function impairment, which persists in those who received ECMO-treatment. Especially for them long-term follow up is recommended. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 de Munck, van der Cammen-van Zijp, Zanen-van den Adel, Wijnen, Cochius-den Otter, van Haren, Gischler, van Rosmalen and IJsselstijn.)
Databáze:	MEDLINE
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