Pilocytic Astrocytoma-Derived Cells in Peripheral Blood: A Case Report.

Autor:	Volpentesta G; Department of Medical and Surgical Sciences, University 'Magna Græcia', Catanzaro, Italy., Donato G; Department of Health Sciences, University Magna Græcia, Catanzaro, Italy., Ferraro E; Department of Biology, University of Pisa, Pisa, Italy., Mignogna C; Department of Health Sciences, University Magna Græcia, Catanzaro, Italy., Radaelli R; Department of Medical and Surgical Sciences, University 'Magna Græcia', Catanzaro, Italy., Sabatini U; Department of Medical and Surgical Sciences, University Magna Græcia, Catanzaro, Italy., La Torre D; Department of Medical and Surgical Sciences, University 'Magna Græcia', Catanzaro, Italy., Malara N; Department of Experimental and Clinical Medicine, University Magna Græcia, Catanzaro, Italy.
Jazyk:	angličtina
Zdroj:	Frontiers in oncology [Front Oncol] 2021 Oct 27; Vol. 11, pp. 737730. Date of Electronic Publication: 2021 Oct 27 (Print Publication: 2021).
DOI:	10.3389/fonc.2021.737730
Abstrakt:	Imaging limitations, invasive tissue biopsies and poor information over the course of treatment to evaluate 'real-time' tumor dynamics justify the emerging use of liquid biopsies in the field of brain tumors. Circulating tumor cells (CTCs) from high-grade astrocytomas might reach the circulation by crossing the blood-brain barrier. Here, for the first time, CTCs cytology in a case of pylocitic astrocytoma is described. An obstructive hydrocephalous due to a lateral mesencephalic tectum mass occluding the Silvio Aqueduct was diagnosed in a young, 18 years old, male. Considering the location of the tumor and the rapid deterioration of the neurological status, it has been decided to urgency treat the patient with ventriculoperitoneal shunting. Magnetic resonance imaging showed a nodular shaped lesion localized within the left lateral mesencephalic tectum. Stereotactic biopsy was not approachable due significant risk of neurological consequences. The diagnosis was performed by blood sampling, a non-invasive procedure for the patient, in order to provide tumor information. Cytopathological features on detected circulating atypical GFAP positive cells led to pilocytic diagnosis confirmed by the patient's 68 months outcome. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Volpentesta, Donato, Ferraro, Mignogna, Radaelli, Sabatini, La Torre and Malara.)
Databáze:	MEDLINE
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