Mechanosensitive pathways are regulated by mechanosensitive miRNA clusters in endothelial cells.

Autor: Herault S; School of Engineering and Materials Science, Queen Mary University of London, Room 2.14, London, UK., Naser J; NHLI, Imperial College London, London, UK., Carassiti D; School of Engineering and Materials Science, Queen Mary University of London, Room 2.14, London, UK., Chooi KY; School of Engineering and Materials Science, Queen Mary University of London, Room 2.14, London, UK., Nikolopoulou R; Department of Bioengineering, Imperial College London, London, UK., Font ML; School of Engineering and Materials Science, Queen Mary University of London, Room 2.14, London, UK., Patel M; NHLI, Imperial College London, London, UK., Pedrigi R; College of Engineering, Mechanical & Materials Engineering, University of Nebraska-Lincoln, Lincoln, Nebraska, USA., Krams R; School of Engineering and Materials Science, Queen Mary University of London, Room 2.14, London, UK.
Jazyk: angličtina
Zdroj: Biophysical reviews [Biophys Rev] 2021 Oct 23; Vol. 13 (5), pp. 787-796. Date of Electronic Publication: 2021 Oct 23 (Print Publication: 2021).
DOI: 10.1007/s12551-021-00839-0
Abstrakt: Shear stress is known to affect many processes in (patho-) physiology through a complex, multi-molecular mechanism, termed mechanotransduction. The sheer complexity of the process has raised questions how mechanotransduction is regulated. Here, we comprehensively evaluate the literature about the role of small non-coding miRNA in the regulation of mechanotransduction. Regulation of mRNA by miRNA is rather complex, depending not only on the concentration of mRNA to miRNA, but also on the amount of mRNA competing for a single mRNA. The only mechanism to counteract the latter factor is through overarching structures of miRNA. Indeed, two overarching structures are present miRNA families and miRNA clusters, and both will be discussed in details, regarding the latest literature and a previous conducted study focussed on mechanotransduction. Both the literature and our own data support a new hypothesis that miRNA-clusters predominantly regulate mechanotransduction, affecting 65% of signalling pathways. In conclusion, a new and important mode of regulation of mechanotransduction is proposed, based on miRNA clusters. This finding implicates new avenues for treatment of mechanotransduction and atherosclerosis.
(© Crown 2021.)
Databáze: MEDLINE
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