Clinical manifestations, complications, and outcomes of patients with COVID-19 in Sudan: a multicenter observational study.

Autor: Hasabo EA; Faculty of Medicine, University of Khartoum, ElQasr Avenue, Khartoum, Khartoum state, 11111, Sudan. elfatih.ahmed.hasabo@gmail.com., Ayyad FA; School of Medicine, Ahfad University for Women, Khartoum, Sudan., Alam Eldeen SAM; Faculty of Medicine, University of Khartoum, ElQasr Avenue, Khartoum, Khartoum state, 11111, Sudan., Noureldaim MK; Faculty of Medicine, National Ribat University, Khartoum, Sudan., Abdallah TA; Faculty of Medicine, University of Khartoum, ElQasr Avenue, Khartoum, Khartoum state, 11111, Sudan., Ahmed YT; Faculty of Medical Laboratory, University of Alzaiem Alazhari, Khartoum, Sudan., Badi S; Faculty of Pharmacy, Omdurman Islamic University, Khartoum, Sudan., Khalid WK; Sudan Medical Specialization Board, Khartoum, Sudan., Mirghani HA; School of Medicine, Ahfad University for Women, Khartoum, Sudan., Mohammed YA; Federal Ministry of Health, Khartoum, Sudan., Alkhider LA; Faculty of Medicine, University of Khartoum, ElQasr Avenue, Khartoum, Khartoum state, 11111, Sudan., Hamad SA; Faculty of Medicine, University of Khartoum, ElQasr Avenue, Khartoum, Khartoum state, 11111, Sudan., Tagelseed AM; Faculty of Medicine, University of Khartoum, ElQasr Avenue, Khartoum, Khartoum state, 11111, Sudan., Elsheikh EHA; Faculty of Medicine, University of Khartoum, ElQasr Avenue, Khartoum, Khartoum state, 11111, Sudan., Khalid NH; Faculty of Medicine, University of Khartoum, ElQasr Avenue, Khartoum, Khartoum state, 11111, Sudan., Mohammed SA; Faculty of Medicine, University of Khartoum, ElQasr Avenue, Khartoum, Khartoum state, 11111, Sudan., Elmobark SO; Faculty of Medicine, University of Khartoum, ElQasr Avenue, Khartoum, Khartoum state, 11111, Sudan., Ali OO; Faculty of Medicine, University of Khartoum, ElQasr Avenue, Khartoum, Khartoum state, 11111, Sudan., Mohammed Ali DA; Faculty of Medicine, University of Khartoum, ElQasr Avenue, Khartoum, Khartoum state, 11111, Sudan., Muneer MS; Faculty of Medicine, University of Khartoum, ElQasr Avenue, Khartoum, Khartoum state, 11111, Sudan., Awadalla H; Department of Community Medicine, Faculty of Medicine, University of Khartoum, Khartoum, Sudan., Malik EM; Department of Community Medicine, Faculty of Medicine, University of Khartoum, Khartoum, Sudan.
Jazyk: angličtina
Zdroj: Tropical medicine and health [Trop Med Health] 2021 Nov 14; Vol. 49 (1), pp. 91. Date of Electronic Publication: 2021 Nov 14.
DOI: 10.1186/s41182-021-00382-4
Abstrakt: Background: Coronavirus disease 2019 (COVID-19) is a pandemic caused by a newly discovered coronavirus. Although clinical manifestations of COVID-19 are mainly pulmonary, some patients have other systemic manifestations. This study aimed to describe the clinical finding and outcomes in Sudanese patients diagnosed with COVID-19.
Methods: This retrospective observational study is based on documented files that included patients diagnosed with COVID-19 in seven selected hospitals inside Khartoum. Clinical manifestations, complications and outcomes were extracted from patients' records using an extraction form designed for this study.
Results: Data of 243 patients diagnosed with COVID-19 were analyzed. The mean (SD) age in years was 55.8 (18.4). Out of 116 participants, 27 of them (23.3%) had severe disease, 15 (12.9%) were critically ill. 67.5% of patients were admitted to the hospital within 7 days from onset of symptoms; most of them were admitted to the wards (n = 140,72.5%). Fever (83.2%), cough (70.7%), and shortness of breath (69.2%) were the most commonly recorded clinical manifestations. Sepsis (9.8%) and acidosis (7.8%) were the most frequently reported complications. Death was the final outcome in 21.4% (56/243). Older age and presence of diabetes were found significantly associated with in-hospital death. The laboratory results showed high CRP in 85.6% (119/139), high ferritin in 88.9% (24/27), lactate dehydrogenase had a median of 409.0 (359-760), D-dimer had a median of 3.3 (1.2-16. 6), and 53/105 (50.5%) had low albumin.
Conclusions: Fever was the most mentioned sign among the participants, followed by fatigue. Cough and shortness of breath were the most commonly recorded pulmonary symptoms manifested. Our study showed multiple variables were associated with in-hospital death. The mortality rate was high among severe and critically ill patients diagnosed with COVID-19.
(© 2021. The Author(s).)
Databáze: MEDLINE
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