Identifying SARS-CoV-2 'memory' NK cells from COVID-19 convalescent donors for adoptive cell therapy.

Autor: Herrera L; Research Unit, Basque Center for Blood Transfusion and Human Tissues, Osakidetza, Galdakao, Spain.; Cell Therapy, Stem Cells and Tissues Group, Biocruces Bizkaia Health Research Institute, Barakaldo, Spain., Martin-Inaraja M; Research Unit, Basque Center for Blood Transfusion and Human Tissues, Osakidetza, Galdakao, Spain.; Cell Therapy, Stem Cells and Tissues Group, Biocruces Bizkaia Health Research Institute, Barakaldo, Spain., Santos S; Research Unit, Basque Center for Blood Transfusion and Human Tissues, Osakidetza, Galdakao, Spain.; Cell Therapy, Stem Cells and Tissues Group, Biocruces Bizkaia Health Research Institute, Barakaldo, Spain., Inglés-Ferrándiz M; Research Unit, Basque Center for Blood Transfusion and Human Tissues, Osakidetza, Galdakao, Spain.; Cell Therapy, Stem Cells and Tissues Group, Biocruces Bizkaia Health Research Institute, Barakaldo, Spain., Azkarate A; Research Unit, Basque Center for Blood Transfusion and Human Tissues, Osakidetza, Galdakao, Spain.; Cell Therapy, Stem Cells and Tissues Group, Biocruces Bizkaia Health Research Institute, Barakaldo, Spain., Perez-Vaquero MA; Research Unit, Basque Center for Blood Transfusion and Human Tissues, Osakidetza, Galdakao, Spain.; Cell Therapy, Stem Cells and Tissues Group, Biocruces Bizkaia Health Research Institute, Barakaldo, Spain., Vesga MA; Research Unit, Basque Center for Blood Transfusion and Human Tissues, Osakidetza, Galdakao, Spain.; Cell Therapy, Stem Cells and Tissues Group, Biocruces Bizkaia Health Research Institute, Barakaldo, Spain., Vicario JL; Histocompatibility, Centro de Transfusión de Madrid, Madrid, Spain., Soria B; Instituto de Bioingeniería, Universidad Miguel Hernández de Elche, Alicante, Spain.; Instituto de Investigación Sanitaria Hospital General y Universitario de Alicante (ISABIAL), Alicante, Spain., Solano C; Hospital Clínico Universitario de Valencia/Instituto de Investigación Sanitaria INCLIVA, Valencia, Spain.; School of Medicine, University of Valencia, Spain., De Paz R; Hematology Department, University Hospital La Paz, Madrid, Spain., Marcos A; Hematology Department, University Hospital La Paz, Madrid, Spain., Ferreras C; Hospital La Paz Institute for Health Research, IdiPAZ, University Hospital La Paz, Madrid, Spain., Perez-Martinez A; Hospital La Paz Institute for Health Research, IdiPAZ, University Hospital La Paz, Madrid, Spain.; Pediatric Hemato-Oncology Department, University Hospital La Paz, Madrid, Spain.; Faculty of Medicine, Universidad Autónoma de Madrid, Madrid, Spain., Eguizabal C; Research Unit, Basque Center for Blood Transfusion and Human Tissues, Osakidetza, Galdakao, Spain.; Cell Therapy, Stem Cells and Tissues Group, Biocruces Bizkaia Health Research Institute, Barakaldo, Spain.
Jazyk: angličtina
Zdroj: Immunology [Immunology] 2022 Feb; Vol. 165 (2), pp. 234-249. Date of Electronic Publication: 2021 Dec 02.
DOI: 10.1111/imm.13432
Abstrakt: COVID-19 disease is the manifestation of syndrome coronavirus 2 (SARS-CoV-2) infection, which is causing a worldwide pandemic. This disease can lead to multiple and different symptoms, being lymphopenia associated with severity one of the most persistent. Natural killer cells (NK cells) are part of the innate immune system, being fighting against virus-infected cells one of their key roles. In this study, we determined the phenotype of NK cells after COVID-19 and the main characteristic of SARS-CoV-2-specific-like NK population in the blood of convalescent donors. CD57+ NKG2C+ phenotype in SARS-CoV-2 convalescent donors indicates the presence of 'memory'/activated NK cells as it has been shown for cytomegalovirus infections. Although the existence of this population is donor dependent, its expression may be crucial for the specific response against SARS-CoV-2, so that, it gives us a tool for selecting the best donors to produce off-the-shelf living drug for cell therapy to treat COVID-19 patients under the RELEASE clinical trial (NCT04578210).
(© 2021 The Authors. Immunology published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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