A comparative evaluation of dietary exposure to glyphosate resulting from recommended U.S. diets.

Autor: Louie F; Cardno ChemRisk; 235 Pine Street, Suite 2300, San Francisco, CA, 94105, United States. Electronic address: Fian.Louie@cardno.com., Jacobs NFB; Cardno ChemRisk; 2111 Wilson Blvd, Suite 200, Arlington, VA, 22201, United States. Electronic address: Neva.Jacobs@cardno.com., Yang LGL; Cardno ChemRisk; 235 Pine Street, Suite 2300, San Francisco, CA, 94105, United States. Electronic address: Lisa.Liang@cardno.com., Park C; Cardno ChemRisk; 235 Pine Street, Suite 2300, San Francisco, CA, 94105, United States. Electronic address: Catherine.Park@cardno.com., Monnot AD; Cardno ChemRisk; 235 Pine Street, Suite 2300, San Francisco, CA, 94105, United States. Electronic address: Andrew.Monnot@cardno.com., Bandara SB; Cardno ChemRisk; 235 Pine Street, Suite 2300, San Francisco, CA, 94105, United States. Electronic address: Suren.Bandara@boehringer-ingelheim.com.
Jazyk: angličtina
Zdroj: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2021 Dec; Vol. 158, pp. 112670. Date of Electronic Publication: 2021 Nov 11.
DOI: 10.1016/j.fct.2021.112670
Abstrakt: Since its commercial introduction in 1974, national and international regulatory agencies have consistently reported no human health concerns associated with the herbicide glyphosate when used according to label directions. However, in 2015, the International Agency for Research on Cancer (IARC) classified glyphosate as a probable human carcinogen. Despite IARC being the sole outlier in its conclusion, dietary exposure to glyphosate remains a health concern to some members of the public. While glyphosate residues have been detected in foods, it is unclear whether a specific eating pattern substantially contributes to glyphosate exposure. Therefore, dietary glyphosate intake was determined for three eating patterns recommended in the U.S. The 95th percentile of glyphosate ingestion at 2,000 calories/day for adults for the U.S.-Style, Mediterranean-Style, and Vegetarian eating patterns ranged from 38 to 960, 39 to 1100, and 39 to 880 μg/day, respectively. No significant differences were observed in glyphosate intake between the dietary styles, and the 95th percentile glyphosate intakes were well below the current U.S. EPA chronic oral reference dose (RfD) of 0.1 mg/kg/day. Our data demonstrate that ingestion of certain high residue foods, particularly grains and legumes, is a driver of total dietary glyphosate body burden regardless of dietary style.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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